Home-Based CAREFit-BMT Exercise Program to Improve Heart Function in High-Risk Acute Myeloid Leukemia Patients Preparing for Stem Cell Transplant

What This Trial Is About

Researchers are evaluating a home-based exercise program called Cardiorespiratory Fitness in Bone Marrow Transplant Program CAREFit-BMT to improve heart function in patients with high-risk acute myeloid leukemia AML who are preparing for stem cell transplants. Older adults and those with other health conditions face higher risks of heart and blood vessel complications after transplant. The program aims to support a safer and more successful transition to stem cell transplant by addressing cardiovascular risks through exercise. Participants will engage in moderate-intensity aerobic exercises at home for 30 minutes, five days a week, along with strength training for 15 to 30 minutes, three days a week, over a period of up to 12 weeks if no unacceptable side effects occur. Throughout the program, blood samples will be collected to monitor health. After completing the exercise intervention, participants will be followed for 12 months to observe longer-term effects. During the study, participants adherence to the exercise program, satisfaction, and feasibility will be assessed. Researchers will measure changes in cardiorespiratory fitness, cardiovascular symptoms, biomarkers, and quality of life from the start until the end of the exercise program. The study will also track recruitment and retention rates over up to 24 months, with ongoing monitoring after intervention completion.

A Home-Based Exercise Intervention (CAREFit-BMT) in Improving Heart Function Among Patients With High Risk Acute Myeloid Leukemia Undergoing Stem Cell Transplant