Dual-task gait speed assessments with an electronic walkway and a stopwatch in older adults. A reliability study.
M Montero-Odasso, Y Sarquis-Adamson, N Kamkar...
https://pubmed.ncbi.nlm.nih.gov/33017671Actively Recruiting
Age: 50Years - 90Years
All Genders
Healthy Volunteers
ID03402919
The Comprehensive Assessment of Neurodegeneration and Dementia Study
Led by McGill University · Updated on 2026-01-20
1573
Participants Needed
19
Research Sites
317 weeks
Total Duration
On this page
Sponsors
M
McGill University
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a long-term observational study involving individuals aged 50 to 90 with various types of dementia, mild cognitive impairments, and a comparison group without cognitive problems. The study includes people with conditions such as Alzheimer's Disease, Parkinson's Disease Dementia, Frontotemporal Dementia, and healthy elderly participants without cognitive complaints. The study started with over 1,000 participants across 30 centers in Canada to better understand these conditions and their progression. Participants undergo thorough initial evaluations including clinical and neuropsychological assessments, genomics, neuroimaging, and biological sample collection from blood, saliva, urine, feces, buccal cells, and cerebrospinal fluid. The study follows participants over time with annual check-ins to track changes in diagnosis and cognition. Additional follow-ups occur at two specific time points to observe longer-term changes, with recruitment continuing for certain non-dementia groups at later phases. During the study, participants will complete ongoing clinical and cognitive tests, brain scans, and provide biological samples. Researchers measure cognitive function using tools like the Montreal Cognitive Assessment (MoCA) over an 8-year period. The study also requires participants to have a study partner to provide additional information. Participation involves yearly re-evaluations to monitor health and cognitive status throughout the study duration, which extends up to several years.
CONDITIONS
Brief Title
Comprehensive Assessment of Neurodegeneration and Dementia
Who Can Participate
Age: 50Years - 90Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Has subjective or objective cognitive impairment
- Written informed consent must be obtained and documented (from the patient or, where allowed, from a caregiver/family member)
- Sufficient proficiency in English or French to complete self-report and neuropsychological testing
- Geographic accessibility to the study site
- Must have a study partner who can participate as required in the protocol
- Up to 12 years of education
- Fits into one of these groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment
You will not qualify if you...
- Presence of other significant chronic brain diseases such as moderate to severe chronic static leukoencephalopathy, multiple sclerosis, serious developmental handicap, malignant tumors, Parkinson's disease (except for Parkinson's cohort), and rarer brain illnesses
- Ongoing alcohol or drug abuse that may interfere with study participation
- Symptomatic stroke within the previous year
- Unable to undergo MRI scan due to medical reasons or intolerance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Baseline visit
Participants undergo comprehensive baseline evaluations including clinical and neuropsychological assessments, neuroimaging, and collection of biological samples.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 8 years
Participants are followed annually to assess changes in diagnosis with repeated evaluations at specified timepoints.
Annual visits and additional evaluations at two longitudinal re-evaluation timepoints
Trial Site Locations
Total: 19 locations
1
University of Calgary
Calgary, Alberta, Canada, T2N 1N4
Actively Recruiting
2
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
3
Djavad Mowafaghian Centre for Brain Health
Vancouver, British Columbia, Canada, V6T 1Z3
Actively Recruiting
4
Island Health
Victoria, British Columbia, Canada, V8R 6R3
Not Yet Recruiting
5
Veteran's Memorial Building
Halifax, Nova Scotia, Canada, B3E 2E1
Actively Recruiting
6
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
7
St. Joseph's Health Care London
London, Ontario, Canada, N6A 4V2
Actively Recruiting
8
Gait and Brain Lab
London, Ontario, Canada, N6C 5J1
Actively Recruiting
9
Bruyère Research Institute
Ottawa, Ontario, Canada, K1N 5C8
Active, Not Recruiting
10
Kawartha Centre
Peterborough, Ontario, Canada, K9H 2P4
Active, Not Recruiting
11
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Active, Not Recruiting
12
University Health Network Memory Clinic
Toronto, Ontario, Canada, M5T 2S8
Active, Not Recruiting
13
Baycrest Clinical Unit
Toronto, Ontario, Canada, M6A 1W1
Actively Recruiting
14
University of Waterloo
Waterloo, Ontario, Canada, N2L 3G1
Active, Not Recruiting
15
Research Institute of the McGill University Health Centre
Montreal, Quebec, Canada, H3G 1A4
Active, Not Recruiting
16
Jewish General Hospital/McGill Memory Clinic
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
17
Clinique de cognition Institut universitaire de gériatrie de Montréal
Montreal, Quebec, Canada, H3W 1W5
Actively Recruiting
18
Hôpital Enfant-Jésus
Québec, Quebec, Canada, G1J 1Z4
Actively Recruiting
19
Centre de recherche sur le vieillissement CIUSSS de l'Estrie-CHUS
Sherbrooke, Quebec, Canada, J1J3H5
Active, Not Recruiting
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Research Team
H
Howard Chertkow, MD
R
Randi Pilon
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
8
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