Study of Brain Activity During Language Processing Using Intracranial Monitoring in Adults with Epilepsy

What this Trial Is About

Researchers are investigating how the human brain processes language by studying neural responses in patients with epilepsy undergoing intracranial monitoring. This study aims to combine detailed brain recordings with computational models to better understand how the brain extracts meaning from speech and sequences of words, focusing on specific brain areas involved in language. Participants are patients with epilepsy who require intracranial monitoring involving the left side of the brain. During the monitoring period, which can last up to about 10 days, participants will listen to sentences and stories while their brain activity is recorded through electrodes placed for clinical reasons. These recordings will help map language processing in the brain and compare it to artificial neural network models. Throughout the study, researchers will collect detailed brain activity data related to language comprehension and analyze cortical maps and neural time-courses during natural speech understanding. Participants will be assessed during their clinical monitoring period, and the study focuses on understanding brain responses rather than testing new treatments. The total participation time aligns with the clinical monitoring duration, and the study includes informed consent and task compliance assessments.

Computational Neuroscience of Language Processing in the Human Brain