Premature Ejaculation

This research investigates a new self-administered digital application designed to improve sexual health, quality of life, and psychological distress among survivors of hematopoietic stem cell transplants (HCT). HCT survivors often face long-term sexual dysfunction due to complex biological, psychological, and social factors, which significantly affect their well-being and relationships. The study aims to address these challenges through a multidisciplinary approach delivered via a digital platform. Participants will be randomly assigned to either use the SHIFT digital application or receive enhanced usual care. The SHIFT app includes interactive features like gamification, survivor videos, intimacy exercises, and optional content to engage users over eight weeks. Those in the usual care group will meet with their clinicians and may be referred to specialists if needed but will not have access to the SHIFT app. During the study, participants will complete assessments measuring sexual satisfaction, function, quality of life, anxiety, and depression at various points up to 24 weeks. Researchers will monitor global satisfaction with sex at week 8 as the primary outcome. The study involves medical evaluations and tracks psychological and physical health through questionnaires and scales, aiming to evaluate the impact of the digital intervention on sexual health outcomes and overall well-being in HCT survivors.

Researchers are evaluating the impact of Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) compared to conventional abdominal laparoscopy (CAL) for benign adnexal surgery in women aged 18 to 70. The study aims to confirm that vNOTES does not negatively affect women's sexual function after surgery, addressing concerns about vaginal scarring and its effects on sexual activity. Secondary goals include assessing vNOTES efficiency, complications, and the quality of histological analysis of surgical specimens. Participants will be randomly assigned to receive either the vNOTES or CAL surgical technique for procedures such as cystectomy, oophorectomy, salpingectomy, or tubal sterilization. Both approaches involve minimally invasive surgery, with vNOTES using the vaginal route and CAL using abdominal laparoscopy. The study also examines pain, hospital stay length, patient satisfaction, and surgical complications during and up to 30 days after surgery. Women in the study will complete questionnaires before surgery and at 3 and 6 months afterward to assess sexual function, couple satisfaction, and pain during sex. Medical and general data will be collected at enrollment, during hospitalization, and one month post-surgery. The main outcomes measured include quality of sexual life and postoperative recovery, while monitoring safety and the effectiveness of both surgical methods throughout the study period.

Researchers are evaluating the effects of the web-based program OMGYES.com on sexual dysfunction in young adult female cancer survivors. This pilot trial aims to assess how feasible, acceptable, and appropriate the intervention is for this group. The study compares outcomes between participants who receive the intervention immediately and those who begin it after a period of observation. Participants will be assigned to one of two groups: an immediate intervention group that starts using OMGYES.com right after enrollment, and a delayed intervention group that undergoes 5 weeks of observation before starting the program. The intervention consists of completing online educational modules at home. During the study, participants will visit the clinic every 5 weeks to complete questionnaires assessing feasibility, acceptability, and appropriateness of the intervention using standardized measures. The main outcome will be measured at the end of the 6-week study period. The trial runs through November 2026 and involves young adult female cancer survivors aged 18 to 45 years.

Researchers are studying how blood samples collected through fingerstick (capillary) compare to traditional venous blood samples for lab testing. This observational study aims to understand the stability of capillary blood samples under different environmental conditions and over time to support the development of lab procedures. The study addresses the need for easier, less distressing blood collection methods to expand diagnostic access and improve disease monitoring remotely. Participants may collect capillary blood themselves or have venous blood drawn by healthcare professionals at designated facilities or their homes. Capillary samples are collected via fingerstick using a lancet, with up to four samples per visit, while venous samples are collected through standard venipuncture methods. Samples are then processed and analyzed under various conditions such as temperature, humidity, light exposure, and freeze-thaw cycles to evaluate specimen stability and assay reliability. Participants provide blood samples either during a single visit or multiple visits over time until withdrawal or study end. The study includes collection of health information and consent, with compensation upon sample submission. Researchers will assess the correlation between capillary and venous samples and monitor sample stability over several days. The study is designed with minimal risk, involving routine procedures and safety monitoring, continuing until study closure or participant withdrawal.

This research aims to compare brain activity during sexual behavior in men with and without primary premature ejaculation, a condition defined by the 2014 International Society for Sexual Medicine criteria. The study uses a controlled design to observe differences between these two groups, focusing on brain function during rest and simulated sexual activity. Participants undergo functional near-infrared spectroscopy (NIRS), a brain imaging technique, to detect brain activity changes in resting and task states. The study includes two groups: men with primary premature ejaculation and men without the condition, matched closely by age. Brain function is monitored during specific tasks related to sexual behavior. During the study, participants will have brain imaging sessions lasting about one hour. Researchers will collect data on brain activity using NIRS during rest and simulated sex tasks. The main outcome measured is the brain imaging results, which will help understand the brain activity differences between the two groups. The study is expected to run until December 2025.

This research aims to evaluate whether the combined use of the EXOMIND (BTL-699-2) and EMSELLA (HPM-6000UF) devices can improve depressive symptoms, sexual function, and urinary incontinence in women who are perimenopausal or postmenopausal, aged 40 years and older, without other medical causes. The study uses a prospective, multi-center, randomized, single-blinded design with two groups to assess safety and efficacy over approximately five months. Participants are randomly assigned in a 3:1 ratio to either an active treatment group or a sham treatment group. The active group receives six sessions of transcranial magnetic stimulation using the BTL-699-2 device over the left dorsolateral prefrontal cortex at intensities up to 70% of their motor threshold, and six treatments with the HPM-6000UF device applied to pelvic floor muscles at intensities up to 100%. The sham group receives similar procedures at minimal intensities (1%). Treatments are spaced 3 to 7 days apart. During the study, participants complete several assessments including the Patient Health Questionnaire-9, Hamilton Depression Rating Scale, Greene Climacteric Scale, International Consultation on Incontinence Questionnaire, Female Sexual Function Index, Warwick-Edinburgh Mental Wellbeing Scale, Columbia Suicide Severity Rating Scale, Therapy Comfort Questionnaire, and Subject Satisfaction Questionnaire. These are completed at baseline, during treatment, and at follow-ups 1 month and 3 months post-treatment. Researchers monitor changes in depressive symptoms, sexual function, urinary incontinence, mental well-being, therapy comfort, satisfaction, and any treatment-related adverse events.

Researchers are evaluating SHAReClinic, a national virtual Sexual Health and Rehabilitation eClinic designed to support prostate cancer patients and their partners. This observational study aims to assess SHAReClinic's impact on improving sexual function, satisfaction, relational intimacy, and overall sexual health after prostate cancer treatment. The goal is to determine SHAReClinic's effectiveness across multiple cancer centers and its role in supporting long-term sexual well-being for patients and couples. Participants will have access to guided education modules and sexual health counseling through SHAReClinic as part of their usual care. The program includes a bio-medical component focused on erectile rehabilitation and a psychological component to maintain or restore intimacy. The study follows patients from before treatment through 12 months post-treatment, with virtual clinic visits scheduled at key recovery milestones, including 6 weeks, 10 weeks, 4 months, 6 months, and 12 months after treatment. Participants will complete questionnaires at baseline, 6 weeks, 6 months, and 12 months to assess sexual function, distress, intimacy, and quality of life. Each virtual clinic visit lasts about 30 minutes and involves a sexual health coach who provides support via phone or video calls. Patients can also engage with a Q&A platform and request additional check-in calls. Researchers will monitor patient satisfaction, enrollment, adherence, and data quality throughout the study, which facilitates ongoing evaluation of SHAReClinic's role in sexual health rehabilitation.

Researchers are studying women who have given birth vaginally at the University Hospitals Leuven to understand pelvic floor dysfunction (PFD) one year after delivery. The study aims to link self-reported PFD symptoms with changes in pelvic floor muscles and evidence of muscle injury using ultrasound imaging. Investigators also want to compare patient characteristics and examine how women recover and follow pelvic floor muscle training during the postpartum period. They are exploring the use of ultrasound images to develop artificial intelligence tools for automated analysis. Women will undergo pelvic floor ultrasound and complete standardized questionnaires that assess urinary, bowel, prolapse, and sexual function at three key times: upon admission to the labor suite, at the postpartum check-up, and one year after delivery. The ultrasound will document pelvic floor muscle anatomy and potential injuries. The questionnaires used include validated tools like the Pelvic Organ Prolapse Distress Index, International Consultation on Incontinence Questionnaire, and Female Sexual Function Index, among others. Participants will be followed for one year postpartum with assessments including ultrasound measurements and symptom questionnaires. Researchers will gather information from medical records about pregnancy and delivery. The main outcomes measured are urinary and anal incontinence, sexual dysfunction, and constipation at one year. Additional outcomes include detailed pelvic floor muscle injury measures and pelvic organ position. This study does not involve blinding or multiple treatment groups, focusing instead on observation and correlation of clinical and imaging findings over time.

Researchers are investigating the attitudes of Danish cancer nurses toward addressing sexual health with their patients. The study aims to understand how these nurses feel about discussing sexual health in their clinical work and to evaluate differences in their perceived knowledge and skills. This observational study uses a questionnaire to gather data from nurses active in oncology and hematology fields in Denmark. The study involves sending out the Health professionals Attitudes towards Sexual Health-Danish version (PA-SH-D) questionnaire electronically to members of the Professional Society for Cancer Nurses via a secure online database. Participants will complete this survey to provide insights into their attitudes and competencies related to sexual health discussions with cancer patients. Nurses who work daily with cancer patients in Danish hospitals or primary care settings are invited to participate. The study measures nurses' attitudes toward addressing sexual health as the primary outcome in July 2024. Participants simply complete the questionnaire online, allowing researchers to collect data on their views and knowledge. The study is sponsored by Rigshospitalet, Denmark, and involves no treatments or clinical interventions beyond questionnaire completion.

Premature ejaculation (PE) is a common sexual dysfunction that can negatively affect quality of life and mental health, especially when anxiety disorders are also present. Researchers are working to create and test a prediction model to identify PE patients at high risk of developing anxiety disorders. This model aims to help with early treatments and improve patient care through targeted support. In this observational study, male patients diagnosed with PE will be enrolled from several clinical centers. Participants will undergo assessments including questionnaires, clinical interviews, and medical history reviews to gather data on factors that might predict anxiety disorders. Machine learning will analyze this data to build the prediction model. The model's performance will then be tested using a separate group of patients to verify its accuracy and stability. Participants will be followed for about one year, with anxiety symptoms assessed within three months after PE diagnosis. Researchers will measure the prediction model's accuracy, sensitivity, and specificity in identifying anxiety disorders. The study involves collecting detailed patient information through interviews and questionnaires. This research could lead to better personalized care for those at risk of anxiety related to PE.