Multiparametric Bone Scintigraphy Analysis to Better Identify Solitary Bone Lesions and Avoid Unnecessary Biopsies

What this Trial Is About

This research aims to evaluate the use of non-invasive Single Photon Emission Computed Tomography combined with Tomodensitometry SPECT-CT bone scintigraphy to better characterize solitary bone lesions. The main goal is to exclude malignancy in these lesions to potentially avoid unnecessary biopsies and their associated complications. The study focuses on multiparametric analysis using new semiconductor camera technology to capture detailed data on bone lesion activity. The study involves a bone scan procedure that includes three stages assessing blood flow perfusion, early tissue uptake, and late bone fixation. Using the SPECT-CT combined with Tomodensitometry, the analysis will quantify the maximum standardized uptake value SUVmax at each stage to help differentiate between benign and malignant lesions. All patients with indeterminate solitary bone lesions scheduled for biopsy or excision are eligible to participate. Participants will undergo the bone scintigraphy scan and data will be collected to assess diagnostic performance, focusing on parameters like Time To Peak and SUVmax at early and late stages. Researchers will evaluate how these measurements help classify solitary bone lesions. The study includes safety monitoring and outcome assessments within 24 hours after the scan. The total participation duration depends on the timing of scheduled biopsy or excision procedures.

Contribution of MUltiparametric Analysis in Bone Scintigraphy for the Characterisation of Solitary Bone Lesions