What this Trial Is About

Researchers are studying how a non-invasive imaging technique called Single Photon Emission Computed Tomography combined with CT (SPECT-CT) bone scintigraphy can better characterize solitary bone lesions. The main goal is to determine if this method can help exclude malignancy without the need for biopsy, potentially avoiding unnecessary procedures and complications. The study focuses on patients with solitary bone lesions that cannot be clearly identified as benign or malignant through conventional imaging. The bone scan used in this study involves three stages: examining blood flow (perfusion), early tissue uptake, and late bone fixation. The new imaging technique allows for detailed analysis and quantification of bone lesions using SUVmax (Standard Uptake Value maximum) at each stage, improving anatomical localization compared to traditional planar images. This multiparametric approach uses advanced semiconductor cameras for better imaging quality. Participants will undergo the three-stage bone scintigraphy procedure. Researchers will evaluate the diagnostic accuracy of the Time To Peak parameter within 24 hours. Assessments include detailed image analysis to measure lesion activity and characteristics, aiming to improve diagnosis without invasive biopsy. The study includes adults aged 18 to 90 years with solitary bone lesions needing biopsy consideration and involves social security-affiliated patients who have provided informed consent.

Contribution of MUltiparametric Analysis in Bone Scintigraphy for the Characterisation of Solitary Bone Lesions