Actively Recruiting
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
Led by Akrivia Health · Updated on 2025-10-03
50000
Participants Needed
1
Research Sites
528 weeks
Total Duration
On this page
Sponsors
A
Akrivia Health
Lead Sponsor
C
Cardiff University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved treatments. The investigators will achieve aims by gathering information and biological samples from over 50,000 research participants and then linking this information with participants' electronic health records, genetic and other potential markers of mental illnesses (called biomarkers, derived from biological samples). The investigators will use this resource to analyse how potential risk factors - genetic, other biological and non-biological (related to the participants' life circumstances) - influence participants' experiences, symptoms, and outcomes (both mental and physical health). The investigators will also use advanced analysis to assess whether there may be better ways of grouping together and understanding the experiences of those with severe mental illnesses and dementias. Given the value and importance of this resource for advancing mental health research, the investigators will also make the data available to other researchers to pursue these broad research aims.
CONDITIONS
Official Title
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All participants must have an electronic health record in a primary or secondary care service.
- Mental health participants must have a diagnosis or treatment/referral for major depressive disorder, bipolar disorder, or schizophrenia.
- Participants must be 18 years or older with no upper age limit.
- Participants must be able to speak English.
- Dementia participants must be 18 years or older and currently alive.
- Dementia participants must have been patients in old age psychiatry.
- Dementia participants must have a clinical diagnosis of dementia, mild cognitive impairment, or subjective cognitive impairment, or have been referred to a memory clinic.
- Dementia participants must be willing and able to complete a validated cognitive assessment (MoCA or SLUMS).
- All dementia patients will undergo extended biomarker analysis.
You will not qualify if you...
- Mental health participants who lack capacity to provide consent.
- Dementia participants unable to understand spoken or written English.
- Individuals with intellectual disability.
- Participants with dementia caused by Creutzfeldt-Jakob disease, Huntington's disease, HIV dementia, alcohol-related dementia, intellectual disability, or traumatic brain injury.
- Dementia participants with a diagnosis of depression, psychosis, or bipolar disorder prior to the study period (only for mild cognitive impairment or subjective cognitive impairment patients).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
GlobalMinds central study team
Oxford, Oxford, United Kingdom, OX1 3HJ
Actively Recruiting
Research Team
S
Samantha Yuille, PhD
CONTACT
B
Byron Tibbitts
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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