Actively Recruiting
CUHK Brain Health Longitudinal Study
Led by Chinese University of Hong Kong · Updated on 2026-02-24
5000
Participants Needed
2
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a longitudinal study to understand risk factors contributing to neurological and psychiatric diseases, including stroke, dementia, Alzheimer's disease, and brain ischemia. This study aims to gather detailed information from individuals diagnosed with or at high risk for these brain conditions, as well as healthy participants interested in brain health. The goal is to identify factors that affect brain health over time and find ways to preserve and promote it by tracking participants' progress. Participants are grouped into three categories: those with established neurological or psychiatric diagnoses (Red group), those at high risk due to family history or early signs (Yellow group), and those without such conditions but interested in brain health research (Green group). All groups complete the Neuro-QoL questionnaire assessing various aspects of neurological quality of life. Follow-up occurs about every six months through phone or in-person visits, including repeated questionnaires and screening for new brain-related symptoms or diagnoses. During the study, participants provide medical history and complete questionnaires focusing on social roles, emotional control, fatigue, physical functions, well-being, cognition, anxiety, and depression. Researchers monitor changes over time and correlate these with risk factors. The study does not involve diagnosing or treating conditions but informs participants and their doctors if findings suggest new concerns. Participation includes ongoing assessments over years, with results aiming to improve understanding and care for brain health.
CONDITIONS
Brief Title
CUHK Brain Health Longitudinal Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years of age or older
- Diagnosed with one or more neurological or psychiatric conditions (Red group)
- At high risk for neurological or psychiatric conditions due to family history or early test findings (Yellow group)
- Interested in brain health research without meeting Red or Yellow group criteria (Green group)
- Able and willing to provide informed consent
- Willing to complete health questionnaires and participate in longitudinal follow-up
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline visit
Participants complete the Neuro-QoL questionnaire and, if applicable, additional questions based on clinical diagnosis. Medical history, signs, symptoms, and diagnoses of neurological and psychiatric disorders are recorded. Physicians review these findings and recommend follow-up care as needed.
1 visit (in-person)
Duration - Up to 20 years
Participants are followed longitudinally with repeated Neuro-QoL questionnaires and screening for new neurological or psychiatric signs and symptoms approximately every 6 months. Follow-up may be conducted in person or via phone depending on physician recommendations.
Follow-up visits approximately every 6 months (in-person or phone)
Trial Site Locations
Total: 2 locations
1
Chinese University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
2
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
T
Thomas Wai Hong LEUNG, FRCP
T
Tiffany Chung, M.Phil
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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