Actively Recruiting
Effectiveness of Daily Bitemporal Low-frequency Transcranial Random Noise Stimulation in Patients With Chronic Tinnitus
Led by University of Regensburg · Updated on 2025-09-19
30
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic tinnitus is a condition where people hear sounds without any external source, often caused by changes in the brain's auditory pathways. This condition can greatly affect daily life, and current treatments are difficult. Researchers are studying whether daily low-frequency transcranial random noise stimulation (tRNS) applied to both sides of the auditory cortex can help reduce the symptoms of chronic tinnitus in a pilot trial. The study involves using a device to deliver low-frequency tRNS at less than 100Hz with a 2mA current for 20 minutes each day over the left and right auditory cortex. The treatment is applied with specific electrodes placed over the brain areas related to hearing. This treatment will be given daily for two weeks to see if it is safe, feasible, and helpful for patients with chronic tinnitus. Participants will undergo assessments at multiple time points, including week 2, week 4, and week 12 after treatment begins. Researchers will measure the number of participants who respond to treatment at week 12 and track changes in tinnitus severity using questionnaires and numeric rating scales. Safety and long-term effects will be monitored throughout the study period, which supports understanding how this brain stimulation affects chronic tinnitus over time.
CONDITIONS
Brief Title
Daily Bitemporal Low-frequency Transcranial Random Noise Stimulation in Tinnitus (tRNS2-tin)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of bothersome, subjective chronic tinnitus
- Duration of tinnitus more than 6 months
- Age between 18 and 70 years
You will not qualify if you...
- Objective tinnitus
- Irregular head shape below the electrodes
- Eczema on the head
- Treatable cause of the tinnitus
- Participation in other treatments for tinnitus at the same time
- Clinically relevant psychiatric comorbidity
- Clinically relevant unstable internal or neurological comorbidity
- History or evidence of significant brain malformation or neoplasm, head injury
- Cerebral vascular events
- Neurodegenerative disorder affecting the brain or prior brain surgery
- Metal objects in and around body that cannot be removed
- Pregnancy
- Alcohol or drug abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 weeks
Participants receive daily low-frequency transcranial random noise stimulation (lf-tRNS) over both auditory cortices.
Daily sessions for 2 weeks
Duration - Up to 10 weeks after treatment
Participants are monitored for treatment response and changes in tinnitus symptoms.
Visits at Week 2, Week 4, and Week 12
Trial Site Locations
Total: 1 location
1
University of Regensburg - Deptartment of Psychiatry
Regensburg, Germany, 93053
Actively Recruiting
Research Team
B
Berthold Langguth
M
Martin Schecklmann
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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