Actively Recruiting
DC Longitudinal Study on Aging and Specimen Bank
Led by Georgetown University · Updated on 2019-10-24
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers at Georgetown University's Memory Disorders Program are conducting studies to evaluate various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases. The research aims to assess the feasibility of biochemical assays, genetic testing, and cognitive and lifestyle assessments to aid in early diagnosis. The study includes participants with probable diagnoses of these conditions as well as normal controls. Participants can choose to take part in the main study alone or also join a longitudinal substudy. The main study involves a single visit for collecting demographic and medical information, brief cognitive testing, and blood and/or optional cerebrospinal fluid samples. Genetic testing will be performed, but no clinical lab results are shared with participants. Those in the longitudinal substudy will have follow-up visits annually or every two years depending on their cognitive status group, with telephone check-ins for some participants. During participation, individuals will undergo cognitive testing, lifestyle questionnaires, and specimen collection at scheduled intervals. Those with normal cognition will attend clinic visits every other year with phone visits in between, while those with cognitive disorders will have yearly clinic visits. Specimens will be stored for future research and may be shared in a de-identified way to support further studies. The primary outcome measured is the Clinical Dementia Rating over nine years, and the study is expected to continue until January 2027.
CONDITIONS
Brief Title
DC Longitudinal Study on Aging and Specimen Bank
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 and older
- Participants aged 45 to 50 years must have a first-degree relative with a neurodegenerative disease
You will not qualify if you...
- Individuals under 45 years of age
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single visit
Participants undergo assessments including demographic and medical information collection, cognitive testing, and optional blood and cerebrospinal fluid specimen collection for research.
1 visit (in-person)
Duration - Up to 9 years
Participants return for ongoing longitudinal study visits with cognitive testing, lifestyle questionnaires, and specimen collection. Visits occur yearly for those with cognitive disorders and every other year for cognitively normal participants, with telephone check-ins on alternating years.
Yearly or every other year clinic visits depending on cognitive status, with telephone visits on alternating years for cognitively normal participants
Trial Site Locations
Total: 1 location
1
Georgetown University Memory Disorders Program
Washington D.C., District of Columbia, United States, 20057
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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