Actively Recruiting

Phase Not Applicable
Age: 60Years +
All Genders
Healthy Volunteers
ID04962061

Impacts of Aerobic, Resistance and Cognitive Training Interventions on Neurocognitive Functions in Older Adults With Cardiovascular Risk Factors

Led by Louis Bherer · Updated on 2025-02-06

159

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

L

Louis Bherer

Lead Sponsor

C

Canadian Institutes of Health Research (CIHR)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are evaluating how a combined program of aerobic and resistance exercises along with cognitive training affects brain function in older adults aged 60 and above. The study focuses on people who are sedentary and may or may not have cardiovascular risk factors like diabetes, high blood pressure, or high cholesterol, conditions known to impact memory and attention. This trial aims to compare the effects of physical exercise alone versus combined physical and cognitive training on thinking skills and brain health. The trial includes three groups: one group will do both cognitive and physical training, another will do only aerobic and resistance exercises, and the third group will perform stretching and toning exercises as an active control. Each group participates in three sessions per week for 46 weeks, with options to train at home or at a center. The physical exercise sessions include warm-up, moderate to vigorous aerobic activity monitored by heart rate, and resistance training, while cognitive training involves computer-based memory and attention tasks. Participants will undergo assessments at the start and after 12 months to measure changes in general cognition, processing speed, executive functions, and memory. Brain imaging and blood flow measures will also be evaluated to observe changes in brain structure and function. Throughout the study, participants will be monitored for exercise intensity and adherence. The total study duration covers 12 months, with safety and cognitive outcomes closely tracked to understand the impact of these interventions.

CONDITIONS

Brief Title

A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

Who Can Participate

Age: 60Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult aged 60 and older
  • Normal or corrected vision and normal hearing for their age range
  • No cognitive impairment (Mini-Mental State Examination - MMSE 65 25)
  • Inactive (less than 150 minutes of physical activity per week)
Not Eligible

You will not qualify if you...

  • MMSE 24 or less or diagnosis of dementia
  • Uncontrolled psychological or psychiatric condition within the past 6 months
  • Neurological disease
  • Severe exercise intolerance
  • Respiratory disease such as asthma or COPD
  • Excessive alcohol consumption (more than 15 drinks per week)
  • Documented cerebral, peripheral or coronary atherosclerotic disease
  • Chronic systolic or diastolic heart failure
  • Symptomatic aortic stenosis
  • Atrial fibrillation
  • Automatic implantable defibrillator or permanent pacemaker
  • Malignant exertional arrhythmias
  • Non-cardiopulmonary limitation to exercise such as arthritis

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 46 weeks

Participants will engage in one of three interventions: a combined cognitive training with aerobic and resistance exercises, physical exercise only, or stretching and toning exercises. Each intervention involves three 60-minute sessions per week, which participants may complete either at home or at a center.

Weekly sessions, three times per week

Follow-up

Duration - Up to 12 months from baseline

Participants will undergo assessments to evaluate changes in cognitive functions and brain imaging outcomes after completing the intervention.

1 post-intervention visit (in-person)

Trial Site Locations

Total: 1 location

1

Preventive medicine and physical activity centre (centre EPIC), Montreal Heart Institute

Montreal, Quebec, Canada, H1T1N6

Actively Recruiting

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Research Team

L

Louis Bherer, PhD

A

Anil Nigam, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

3

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Published Research Related To This Trial

Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease.

Laura D Baker, Laura L Frank, Karen Foster-Schubert...

https://pubmed.ncbi.nlm.nih.gov/20847403

Training effects on dual-task performance: are there age-related differences in plasticity of attentional control?

Louis Bherer, Arthur F Kramer, Matthew S Peterson...

https://pubmed.ncbi.nlm.nih.gov/16420143

Brain imaging changes associated with risk factors for cardiovascular and cerebrovascular disease in asymptomatic patients.

Joseph I Friedman, Cheuk Y Tang, Hans J de Haas...

https://pubmed.ncbi.nlm.nih.gov/25323165