Actively Recruiting
Deciphering the Interactions Between Food Intake, Sleepiness, and Nighttime Sleep Quality in Patients With Type 1 Narcolepsy and Idiopathic Hypersomnia
Led by Hospices Civils de Lyon · Updated on 2026-06-03
76
Participants Needed
2
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the complex links between sleep and food intake, focusing on patients with Narcolepsy type 1 (NT1), idiopathic hypersomnia (IH), and healthy individuals. The study aims to understand why obesity is common in 30-50% of NT1 patients but rare in IH patients, exploring how diet, body composition, and sleep patterns interact in these groups. This research may help reveal causes of obesity in narcolepsy and how food affects sleepiness. Participants will be monitored over several days for eating behaviors, including meal photos and sugar intake using a sensor that measures glucose levels. Sleep and wake rhythms will be tracked with diaries and actigraphy devices. Nocturnal sleep quality and quantity will be measured using a portable device that records sleep patterns and brain activity. Sleepiness will be assessed with a sleepiness scale and EEG markers before and after meals. During the study, participants will provide data on body mass index, body composition, and complete questionnaires about sleep quality, anxiety, depression, and eating behaviors. The study will measure how glycemic load affects sleepiness at various times after food intake and examine the timing, quantity, and quality of food consumed. Researchers will also explore the relationship between glucose levels and sleepiness markers. The total participation involves clinical evaluations and home monitoring over several days to better understand dietary and sleep interactions.
CONDITIONS
Brief Title
Deciphering the Interactions Between Food Intake, Sleepiness, and Nighttime Sleep Quality in Patients With Type 1 Narcolepsy and Idiopathic Hypersomnia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with Narcolepsy type 1 or Idiopathic Hypersomnia diagnosed by ICSD-3-TR, or healthy controls without sleep disorders
- Familiarity with using a smartphone
- Age between 18 and 65 years
You will not qualify if you...
- Untreated moderate or severe sleep apnea syndrome
- Cognitive disorders incompatible with the study protocol
- Unstable treatment or treatment with sodium oxybate
- Unstable medical or psychiatric conditions
- Shift work
- Pregnancy or breastfeeding
- Diabetes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Duration - 4 to 5 days
Participants will monitor their eating behaviors by taking pictures of consumed food and drinks daily for 4 days, and wear a sensor measuring glucose levels continuously. They will also keep a sleep diary and wear actigraphy and a portable sleep device to record sleep quality and sleepiness markers during this period.
Daily self-monitoring and device use over 4 to 5 days
Duration - Up to 4 days (between day 4 and day 7)
Participants undergo a calibrated glucose load test between day 4 and day 7, with continuous monitoring of glucose levels and assessments of subjective and objective markers of sleepiness over 2 hours following the test.
1 visit for glucose load test with 2 hours of monitoring
Trial Site Locations
Total: 2 locations
1
Unité de Neurophysiologie-sommeil, Département de Neurologie, CHU de Clermont-Ferrand
Clermont-Ferrand, France, 63000
Not Yet Recruiting
2
Center for Sleep Medicine, Hospices Civils de Lyon
Lyon, France, 69004
Actively Recruiting
Research Team
L
Laure PETER-DEREX, MD-PhD
S
Solène PANTEL
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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