Understanding How Food Intake Affects Sleepiness and Nighttime Sleep Quality in Adults with Type 1 Narcolepsy and Idiopathic Hypersomnia

What this Trial Is About

Researchers are studying the complex links between sleep and food intake, focusing on patients with Narcolepsy type 1 NT1, idiopathic hypersomnia IH, and healthy individuals. The study aims to understand why obesity is common in 30-50% of NT1 patients but rare in IH patients, exploring how diet, body composition, and sleep patterns interact in these groups. This research may help reveal causes of obesity in narcolepsy and how food affects sleepiness. Participants will be monitored over several days for eating behaviors, including meal photos and sugar intake using a sensor that measures glucose levels. Sleep and wake rhythms will be tracked with diaries and actigraphy devices. Nocturnal sleep quality and quantity will be measured using a portable device that records sleep patterns and brain activity. Sleepiness will be assessed with a sleepiness scale and EEG markers before and after meals. During the study, participants will provide data on body mass index, body composition, and complete questionnaires about sleep quality, anxiety, depression, and eating behaviors. The study will measure how glycemic load affects sleepiness at various times after food intake and examine the timing, quantity, and quality of food consumed. Researchers will also explore the relationship between glucose levels and sleepiness markers. The total participation involves clinical evaluations and home monitoring over several days to better understand dietary and sleep interactions.

Deciphering the Interactions Between Food Intake, Sleepiness, and Nighttime Sleep Quality in Patients With Type 1 Narcolepsy and Idiopathic Hypersomnia