Actively Recruiting
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
Led by The Cleveland Clinic · Updated on 2025-07-03
12
Participants Needed
1
Research Sites
188 weeks
Total Duration
On this page
Sponsors
T
The Cleveland Clinic
Lead Sponsor
R
Raynor Cerebellum Project
Collaborating Sponsor
AI-Summary
What this Trial Is About
This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System. The population will consist of patients that have either failed a prior intervention (Vim DBS or HIFU thalamotomy) or determined to not be suitable candidates for Vim DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor. Those patients with a previous intervention, must have a prior diagnosis of ET, cerebellar outflow tremor, or MS-related tremor. Subjects without a previous intervention must have a diagnosis of cerebellar outflow tremor or MS-related tremor.
CONDITIONS
Official Title
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21 years and older;
- Ability to give informed consent;
- Diagnosis of ET, cerebellar tremor, or MS-related tremor with a failed a prior intervention (VIM DBS or HIFU thalamotomy) or determined to not be suitable candidates for VIM DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor.
- Tremor history of at least three years;
- Tremor that is refractory to medical management;
- A score of ≥24 on the Mini Mental State Examination;
- Inability to successfully perform ADLs without assistance or has lost interest in social, professional, or personal activities due to tremor
You will not qualify if you...
- Any other neurological condition that could reduce the safety of study participation including central nervous system vasculitis and intracranial malignancy
- A condition that, in the opinion of the clinical investigator, would significantly increase the risk or interfere with study compliance, safety, or outcome;
- A diagnosis of dementia;
- Tremors due to other neurological conditions such as Parkinson's disease, dystonia, or other conditions not consistent with ET, cerebellar outflow tremor, or MS-related tremor.
- Diagnosis of epilepsy;
- Major active and untreated psychiatric illness that may interfere with study, such as psychotic disorders or severe personality disorders;
- Untreated or inadequately treated depression defined by a score of 20 or greater on the Beck Depression Inventory-II at the time of enrollment;
- At risk for suicide defined by a score greater or equal to 3 on the Columbia Suicide Severity Rating Scale (C-SSRS);
- Pregnancy;
- Unable to communicate with investigators or staff;
- Surgical contraindications to DN DBS;
- Contraindication to magnetic resonance (MRI) imaging, e.g., weight incompatible with scanner, implanted metallic devices or electrical devices (pacemaker, defibrillator, spinal cord stimulator, prior DBS) or intolerance to MRI contrast agent;
- Enrolled in another device, biologic or pharmaceutical study within 30 days of consent in the current study, (i.e., patient cannot be enrolled if participation in another study was not completed at least 30 days prior to consent.);
- Evidence of behavior(s) consistent with alcohol or substance abuse/dependence as defined by the criteria outlined in the DSM-V within the preceding six months;
- Injection of botulinum toxins into the arm, neck or face within six months prior to baseline;
AI-Screening
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Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
J
Jeffrey Negrey, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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