Actively Recruiting
Algorithms for Programming DBS Systems for ET
Led by University of Minnesota · Updated on 2026-01-27
25
Participants Needed
1
Research Sites
639 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Deep brain stimulation (DBS) targeting the Vim thalamus (ventralis intermedius nucleus) is an FDA-approved neuromodulation therapy for treating postural and action tremor in individuals with essential tremor (ET). The success of this treatment, however, is highly dependent on the ability of clinicians to identify therapeutic stimulation settings through a laborious programming process. There is a strong and growing clinical need for new approaches to provide clinicians with more efficient guidance on how to titrate stimulation settings. This study will leverage subject-specific computational models that can predict neural activation of axonal pathways adjacent to the active electrode(s) and implicated in the therapeutic mechanisms of Vim-DBS to in turn guide clinicians with which stimulation settings are likely to be the most therapeutic on tremor.
CONDITIONS
Official Title
Algorithms for Programming DBS Systems for ET
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of essential tremor
- Tremor that does not respond to medication
- Having a VIM-DBS implant, either on one or both sides
- Completed a 7-Tesla MRI scan before surgery under Dr. Harel's IRB protocol (#1210M22183)
- Completed a post-operative CT scan
You will not qualify if you...
- History of musculoskeletal disorders affecting limb movement
- Having other significant neurological disorders
- Previous stereotactic neurosurgery except VIM-DBS surgery
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
M
Matthew Johnson, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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