Phase 2 Study of Targeted Radiation Therapy for Patients With High-Risk Cancer Spread to the Spine

What this Trial Is About

Researchers are evaluating whether patients with cancer that has aggressively spread to the spine can be treated with stereotactic body radiation therapy SBRT alone, potentially avoiding major spine surgery. This phase II study focuses on patients with high-risk spinal metastases, aiming to understand the effects of this less invasive treatment approach compared to traditional surgical options. Participants receive SBRT targeted specifically to spine metastases. The study involves a single treatment group where this precise radiation therapy is administered to up to three adjacent vertebral bodies affected by metastatic solid tumors. This approach is designed to manage the cancer spread while preserving neurologic function and avoiding more invasive procedures. During the study, participants undergo assessments including imaging and various disability and quality-of-life questionnaires at one, three, and six months after treatment. Researchers monitor the need for spinal surgery or stabilization within six months, changes in tumor volume, physical disability scores, quality of life, progression-free survival, and overall survival. The total follow-up period extends to six months to evaluate these outcomes and the safety of the SBRT treatment.

Definitive Radiation for High-Risk Spine Metastases