Development of Diaphragm Atrophy, Dysfunction and Inhibited Cortical Control in Mechanical Ventilation

What this Trial Is About

Researchers are investigating the development and recovery of ventilator induced diaphragm dysfunction (VIDD) in patients who require mechanical ventilation (MV) in the intensive care unit. This observational study aims to understand how diaphragm function, strength, and control decline over time during MV, including after removal of the breathing tube. The study also explores whether decreased diaphragm responsiveness from long-term MV affects the brain's motor control of the diaphragm. Participants undergo detailed respiratory muscle testing, including measurements of twitch transdiaphragmatic pressure triggered by magnetic stimulation of the phrenic nerves, and assessments of cortical control of diaphragm function. These tests are performed first within 48 hours of starting MV, then every three days, including two sessions after extubation. Additional evaluations include diaphragm ultrasound and monitoring of systemic inflammation. During the study, patients will have repeated assessments to track changes in diaphragm function and brain control over two years. Researchers will measure twitch pressures, diaphragm muscle activity, and inflammation markers. This helps clarify the rate of diaphragm decline and potential recovery after MV. The study is sponsored by RWTH Aachen University and involves close monitoring of patients in critical care settings.

Diaphragm Atrophy and Dysfunction in Mechanical Ventilation