Actively Recruiting
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
Led by RWTH Aachen University · Updated on 2026-02-09
15
Participants Needed
1
Research Sites
294 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time. Through measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD. Paired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex. Against that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).
CONDITIONS
Official Title
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Initiation of invasive mechanical ventilation in the Intensive Care Unit within 48 hours.
- Expected duration of invasive mechanical ventilation of at least 5 days.
- Age between 18 and 75 years.
You will not qualify if you...
- Body-mass-index (BMI) greater than 40.
- Expected inability to actively participate in study measurements after extubation.
- Alcohol or drug abuse.
- Presence of non MRI compatible implant in the body.
- History of slipped disc.
- Epilepsy.
- Employment or close relationship with the principal investigator, co-investigator, or their deputies.
AI-Screening
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Trial Site Locations
Total: 1 location
1
RWTH Aachen University
Aachen, Germany, 52074
Actively Recruiting
Research Team
M
Michael Dreher, Professor
CONTACT
J
Jens Spiesshoefer, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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