Tracking Diaphragm Weakness and Brain Control Changes in Patients on Mechanical Ventilation Observing Muscle Strength and Recovery After Breathing Support

What this Trial Is About

Researchers are investigating the development and recovery of ventilator induced diaphragm dysfunction VIDD in patients who require mechanical ventilation MV in the intensive care unit. This observational study aims to understand how diaphragm function, strength, and control decline over time during MV, including after removal of the breathing tube. The study also explores whether decreased diaphragm responsiveness from long-term MV affects the brains motor control of the diaphragm. Participants undergo detailed respiratory muscle testing, including measurements of twitch transdiaphragmatic pressure triggered by magnetic stimulation of the phrenic nerves, and assessments of cortical control of diaphragm function. These tests are performed first within 48 hours of starting MV, then every three days, including two sessions after extubation. Additional evaluations include diaphragm ultrasound and monitoring of systemic inflammation. During the study, patients will have repeated assessments to track changes in diaphragm function and brain control over two years. Researchers will measure twitch pressures, diaphragm muscle activity, and inflammation markers. This helps clarify the rate of diaphragm decline and potential recovery after MV. The study is sponsored by RWTH Aachen University and involves close monitoring of patients in critical care settings.

Diaphragm Atrophy and Dysfunction in Mechanical Ventilation