Effects of Healthy Versus Western-Style Diets on Sleep Quality, Daily Rhythms, and Body Functions in Adults Aged 18 to 32

What this Trial Is About

Researchers are investigating how different diets affect sleep and related body functions such as metabolism, heart activity, and hormone levels. This study compares the effects of a Western-style unhealthy diet with a healthier, fiber-rich diet on both objective and subjective sleep measures, along with various biomarkers linked to heart and metabolic health, brain function, and gut microbiota. The goal is to understand how nutrition influences sleep quality and overall physiological health. The study uses a randomized crossover design where participants follow two diet interventions a low-fat diet and a high-fat diet. Each diet is followed for about one week in daily life, then participants spend approximately two days in a controlled laboratory setting for detailed measurements. Participants will wear monitoring devices to track sleep, heart rate, blood pressure, and glucose continuously, along with biological sample collections at multiple times of the day to assess changes in metabolism, immune function, and microbial profiles. Participants will undergo sleep studies using polysomnography and wearables, provide repeated biological samples, and complete tests evaluating cognitive function, mood, and appetite. Researchers will measure changes in sleep structure, 24-hour heart rate variability, glucose levels, blood pressure, and various biomarkers over up to nine days on each diet. The study includes detailed safety and health monitoring, with total participation lasting about nine to ten days per diet condition.

Dietary Impact on Sleep, Rhythms and Related Physiology