Diurnal Blood Pressure and Arterial Stiffness Patterns in Those at Increased Risk of Cardiovascular Disease

What this Trial Is About

Researchers are studying blood pressure and arterial stiffness patterns over 24 hours in people at increased risk of cardiovascular disease (CVD), including those with kidney conditions such as acute kidney injury, chronic kidney disease, small vessel vasculitis, kidney transplant recipients, and donors. The study aims to understand how natural nighttime drops in blood pressure and arterial stiffness, which protect against CVD, vary in these groups compared to healthy individuals. This research is important because abnormal daily patterns may increase CVD risk and need better characterization to improve treatments. Participants will undergo 24-hour monitoring of blood pressure and arterial stiffness using a Mobil-o-graph device on two separate occasions. Blood and urine samples will also be collected during day and night periods to measure specific markers. The study includes six groups: healthy controls and five patient groups with different kidney-related conditions. This observational study does not involve treatment but focuses on detailed assessment of cardiovascular risk factors. During the study, participants will have ambulatory blood pressure and arterial stiffness measurements alongside scheduled blood and urine tests. Researchers will evaluate nighttime blood pressure and arterial stiffness dips as primary outcomes, as well as changes in specific urine and plasma markers. The study is sponsored by the University of Edinburgh and aims to provide data that may guide targeted cardiovascular risk reduction. Participants will be followed until the study ends in 2026, with visits occurring on two occasions for the assessments.

Diurnal BP Patterns in Those at Increased Risk of CVD