Studying Brain Stimulation to Improve Action Speed After Stroke Using Targeted TMS and EEG in Healthy Adults and Stroke Patients

What this Trial Is About

Stroke often causes long-term disabilities, including slower movement and difficulties with executive functions, which can affect recovery quality. Researchers are studying how specific brain regions interact to control action speed. This study uses advanced brain imaging and stimulation techniques to better understand and potentially improve action speed in stroke patients. The trial involves healthy adults and stroke patients to explore brain network function and rehabilitation approaches. The study is divided into three phases. In the first phase, healthy participants undergo targeted brain stimulation to temporarily disrupt seven key brain areas and see how this affects their action speed. The second phase tests intermittent theta burst stimulation iTBS on the most important brain regions in healthy individuals to assess changes in action speed. In the final clinical phase, stroke patients receive personalized iTBS treatments aimed at improving their action speed, with progress tracked over several months. Participants will be evaluated at the start, immediately after treatment, and at one and three months post-treatment. Assessments include reaction time tasks, brain connectivity measurements using EEG, fNIRS, and dynamic causal modeling, and tests of executive function and daily motor skills. Researchers will compare stroke patients results with healthy controls to refine stimulation techniques and develop personalized rehabilitation strategies to support better recovery after stroke.

Dynamic Causal Modeling of Neuromodulation of Action Speed Via Targeted TMS-EEG