Actively Recruiting
Dynamic Causal Modeling of Neuromodulation of Action Speed Via Targeted TMS-EEG
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-03-12
80
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
C
CHRU LILLE
Collaborating Sponsor
AI-Summary
What this Trial Is About
Stroke is a major cause of long-term disability, with cognitive and motor deficits-especially action slowing and executive dysfunction-being strong predictors of poor recovery outcomes. Recent advances in network neuroscience suggest that action speed is governed by interactions between specific prefrontal and premotor regions. However, the precise neural mechanisms underlying action slowing in stroke remain unclear, limiting the efficacy of current rehabilitation approaches. This study integrates high-density EEG, fNIRS and dynamic causal modeling (DCM), and rTMS to map and modulate the neural circuits involved in action speed. In the first phase, we will assess the role of seven key brain regions in action speed modulation by applying virtual lesions using single-pulse TMS in 60 healthy individuals. In the second phase, we will apply offline intermittent theta burst stimulation (iTBS) to the most relevant regions and evaluate its impact on action speed. Finally, in the clinical phase, we will administer individualized iTBS to 20 stroke patients to enhance action speed. Patients will be assessed at baseline, immediately post-treatment, and after one and three months to track improvements in action speed using DCM and behavioral tests. Changes in connectivity and action speed performance will be compared to healthy controls to refine treatment parameters. Secondary outcomes include executive function and daily life motor performance. Longitudinal follow-up will determine the persistence of improvements, informing future personalized rehabilitation strategies. By characterizing effective connectivity changes post-stroke, we aim to refine neuromodulation strategies and develop a personalized rTMS approach. Our hypothesis is that targeting specific regions identified through integration of EEG, fNIRS and DCM can enhance action speed, ultimately improving functional recovery. This personalized approach could lead to more effective rehabilitation protocols, tailored to individual brain damage patterns.
CONDITIONS
Official Title
Dynamic Causal Modeling of Neuromodulation of Action Speed Via Targeted TMS-EEG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Control participants must be neurologically healthy without medical conditions affecting cognitive performance.
- Control participants must have no contraindications for MRI or TMS, such as epilepsy.
- Patient participants must have had a hemispheric stroke that did not affect key prefrontal regions targeted by the study.
- Patient participants must be free of other cognitive impairments or medical conditions that could affect study results.
You will not qualify if you...
- Participants with neurological, psychiatric, or general conditions known to affect test performance or cognitive function are excluded.
- Participants with any contraindication to MRI and TMS (e.g., epilepsy) are excluded.
- Stroke patients whose MRI shows lesions affecting the prefrontal target areas are excluded.
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHU Amiens
Amiens, Picardie, France, 80000
Actively Recruiting
Research Team
G
GODEFROY Olivier, Pr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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