Actively Recruiting
Dynamic Causal Modeling of Neuromodulation of Action Speed Via Targeted TMS-EEG
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-03-12
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
C
CHRU LILLE
Collaborating Sponsor
AI-Summary
What this Trial Is About
Stroke often causes long-term disabilities, including slower movement and difficulties with executive functions, which can affect recovery quality. Researchers are studying how specific brain regions interact to control action speed. This study uses advanced brain imaging and stimulation techniques to better understand and potentially improve action speed in stroke patients. The trial involves healthy adults and stroke patients to explore brain network function and rehabilitation approaches. The study is divided into three phases. In the first phase, healthy participants undergo targeted brain stimulation to temporarily disrupt seven key brain areas and see how this affects their action speed. The second phase tests intermittent theta burst stimulation (iTBS) on the most important brain regions in healthy individuals to assess changes in action speed. In the final clinical phase, stroke patients receive personalized iTBS treatments aimed at improving their action speed, with progress tracked over several months. Participants will be evaluated at the start, immediately after treatment, and at one and three months post-treatment. Assessments include reaction time tasks, brain connectivity measurements using EEG, fNIRS, and dynamic causal modeling, and tests of executive function and daily motor skills. Researchers will compare stroke patients' results with healthy controls to refine stimulation techniques and develop personalized rehabilitation strategies to support better recovery after stroke.
CONDITIONS
Brief Title
Dynamic Causal Modeling of Neuromodulation of Action Speed Via Targeted TMS-EEG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Control participants must be neurologically healthy without conditions affecting cognitive performance.
- Control participants must have no contraindications for MRI or TMS, such as epilepsy.
- Stroke patients must have experienced a hemispheric stroke that spares key prefrontal brain regions targeted in the study.
- Stroke patients must be free of other cognitive impairments or medical conditions that could affect results.
- Participants must be adults aged 18 years or older.
You will not qualify if you...
- Participants with neurological, psychiatric, or general conditions known to affect test performance or cognitive function are excluded.
- Any contraindications to MRI or TMS, including epilepsy, result in exclusion.
- Stroke patients whose brain lesions affect the prefrontal target structures are excluded.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session
Participants undergo 3D T1-weighted imaging and resting-state functional MRI to identify target brain regions for TMS interventions and assess the impact of temporary disruption on action speed using a reaction time task.
1 visit (in-person)
Duration - Single session
Healthy participants receive intermittent theta burst stimulation (iTBS) to the most relevant brain regions to evaluate its effect on improving action speed.
1 visit (in-person)
Duration - Up to 6 months post-stroke
Stroke patients receive individualized iTBS tailored to enhance action speed, with assessments at multiple time points.
Multiple visits over the study period
Trial Site Locations
Total: 1 location
1
CHU Amiens
Amiens, Picardie, France, 80000
Actively Recruiting
Research Team
G
GODEFROY Olivier, Pr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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