Noninvasive Eye Measurement Using Dynamic Light Scattering to Detect Dementia and Its Types

What this Trial Is About

Researchers are evaluating a noninvasive eye measurement technique called dynamic light scattering spectroscopy to detect differences between patients with and without dementia. The study aims to determine which types and stages of dementia can be identified using this method. Dementia includes various conditions such as Alzheimers disease, vascular dementia, Lewy body dementia, and others, which cause brain changes leading to memory loss and cognitive decline. The study involves an office-based procedure where patients undergo pupil dilation in one eye followed by a 5-second measurement using the dynamic light scattering device attached to a standard fundus camera. This technique measures subtle molecular changes in the retina, which is connected to the brain, to detect early signs of dementia. The study includes two groups patients diagnosed with dementia and age-matched individuals without cerebral pathology. Participants will have an ophthalmic history taken and undergo pupil dilation before the measurement. The test takes about 5 minutes, and the dilation effect lasts 2 to 3 hours. Researchers will collect and analyze data to compare measurements between groups. Safety monitoring is in place, and data confidentiality is maintained. The study is expected to enroll 50 patients and continue until recruitment is complete.

Dynamic Light Scattering Ocular Measurement in the Detection of Dementia