Study of How Antibiotic Resistance Spreads, Persists, and Evolves Between Humans, Dogs, and Their Environment

What this Trial Is About

Antimicrobial resistance AMR is a widespread global health problem affecting humans, animals, and the environment. This research investigates how AMR, particularly resistant bacteria to extended-spectrum cephalosporins and carbapenems, spreads between humans and companion animals like dogs. The study focuses on the potential risk for humans living with pets to acquire these resistant bacteria, using a multidisciplinary approach including epidemiology, ecology, genomics, microbiota studies, modeling, and social sciences. Participants are members of households that own a dog recorded for surgery at the National Veterinary School. The study involves collecting human stool samples six times over a 90-day period alongside questionnaires, and conducting interviews or ethnographic observations with some volunteers. These activities aim to track the transmission and changes in AMR and microbiota between dogs and their owners over three months. Throughout the study, researchers will monitor rates of AMR acquisition in household members and changes in both dog and human microbiota. Sociological factors and behaviors that may increase AMR transmission risk will also be explored through interviews and observations. The main outcome is to generate a list of priorities to prevent and control AMR spread between companion animals and humans, with the total follow-up lasting 90 days.

Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment