Actively Recruiting
Early Prediction of Neoadjuvant Chemotherapy Response in Bladder Cancer Using Quantitative Multiparametric MRI
Led by Assiut University · Updated on 2025-10-02
39
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Bladder cancer is a prevalent malignancy globally, with muscle-invasive disease having a five-year survival rate below 50%. Neoadjuvant chemotherapy (NAC) before radical cystectomy has shown efficacy for resectable muscle-invasive bladder cancer (MIBC). However, non-response to NAC can lead to delayed surgery and unnecessary toxicity. Magnetic resonance imaging (MRI), particularly multiparametric MRI (mpMRI) with dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI), offers functional and quantitative biomarkers that may predict NAC response early in treatment.
CONDITIONS
Official Title
Early Prediction of Neoadjuvant Chemotherapy Response in Bladder Cancer Using Quantitative Multiparametric MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with cT2-T4 urothelial carcinoma of the urinary bladder according to TNM classification
- Patients who give informed, written consent and agree to all study requirements
- Planned to receive cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy
- Willing to undergo three multiparametric MRI scans at specified times
You will not qualify if you...
- Patients who have received pelvic radiotherapy
- Severe renal impairment
- Previous open or laparoscopic pelvic surgery
- Presence of distant metastases at diagnosis
- Patients with contraindications to MRI
- Ineligibility to receive cisplatin chemotherapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Amr E. Darwish
Asyut, Egypt
Actively Recruiting
Research Team
H
Hamza mohamed, MBBCh
CONTACT
A
Amr Darwish, Lecturer
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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