Actively Recruiting
The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach (RADICES)
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2026-05-07
196
Participants Needed
22
Research Sites
247 weeks
Total Duration
On this page
Sponsors
A
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead Sponsor
U
UMC Utrecht
Collaborating Sponsor
AI-Summary
What this Trial Is About
The survival of patients with incurable gastroesophageal cancer can extend over a year with anticancer therapy. However, the number of patients with deteriorating quality of life in this patient group steadily decreases over time during the treatment. Potentially reversible causes related to deterioration of quality of life are diminished muscle mass, physical capacity and nutritional status. Therefore, interventions that can target these in order to maintain or improve quality of life are urgently needed. However, it is yet unknown whether improvement of physical capacity and nutritional status improves quality of life in patients with incurable gastroesophageal adenocarcinoma after failure of first-line treatment. Since these patients are in a precarious situation, the benefits and harms of a combined exercise and nutritional intervention should be carefully evaluated.Therefore this study investigates the effect of a combined exercise and nutrition intervention compared to usual care on quality of life in incurable GAC patients after progression upon first-line treatment. A total of 196 patients with metastasized gastroesophageal cancer will be recruited and randomly allocated 1:1 to standard care or standard care plus a combined exercise and nutritional intervention.
CONDITIONS
Official Title
The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach (RADICES)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Incurable adenocarcinoma of the esophagus or stomach
- Recurrence after curative treatment or irresectable/metastatic disease at diagnosis
- Eligible regardless of plan or start of multi-line systemic treatment
- Able and willing to perform exercise and nutrition program and wear activity tracker
- Able and willing to complete questionnaires
- Life expectancy greater than 12 weeks
- Age 18 years or older
You will not qualify if you...
- Unstable bone metastases causing skeletal fragility
- Untreated symptomatic brain metastases
- Serious active infection
- Too physically active (more than 210 minutes per week of moderate to vigorous exercise)
- Severe neurologic or cardiac impairment
- Uncontrolled severe respiratory insufficiency or oxygen dependency
- Uncontrolled severe pain
- Any contraindication for exercise by physician
- Any condition impairing study adherence or consent ability
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 22 locations
1
Amsterdam UMC
Amsterdam, North Holland, Netherlands, 1081HV
Actively Recruiting
2
UMC Utrecht
Utrecht, Utrecht, Netherlands, 3508GA
Actively Recruiting
3
Jeroen Bosch Hospital
's-Hertogenbosch, Netherlands
Active, Not Recruiting
4
Flevoziekenhuis
Almere Stad, Netherlands
Actively Recruiting
5
Meander Medical Center
Amersfoort, Netherlands
Not Yet Recruiting
6
Reinier de Graaf
Delft, Netherlands
Actively Recruiting
7
Catharina Ziekenhuis
Eindhoven, Netherlands
Actively Recruiting
8
Beatrix Hospital
Gorinchem, Netherlands
Actively Recruiting
9
Spaarne Gasthuis
Hoofddorp, Netherlands
Actively Recruiting
10
Frisius Medical Center
Leeuwarden, Netherlands
Actively Recruiting
11
Leiden Universitair Medisch Centrum
Leiden, Netherlands
Actively Recruiting
12
Sint Antonius Hospital
Nieuwegein, Netherlands
Not Yet Recruiting
13
Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands
Actively Recruiting
14
RadboudUMC
Nijmegen, Netherlands
Actively Recruiting
15
Laurentius Ziekenhuis
Roermond, Netherlands
Actively Recruiting
16
Bravis Ziekenhuis
Roosendaal, Netherlands
Actively Recruiting
17
Erasmus Medical Center
Rotterdam, Netherlands
Actively Recruiting
18
Ikazia Ziekenhuis
Rotterdam, Netherlands
Actively Recruiting
19
HagaZiekenhuis
The Hague, Netherlands
Actively Recruiting
20
Elisabeth Tweesteden Hospital
Tilburg, Netherlands
Actively Recruiting
21
Diakonessenhuis
Utrecht, Netherlands
Not Yet Recruiting
22
Zaans Medical Center
Zaandam, Netherlands
Actively Recruiting
Research Team
A
Aniek Bonhof, Msc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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