Study of How Endobronchial Valves Affect Diaphragm Movement in Adults with Emphysema and COPD

What this Trial Is About

Researchers are investigating the effects of endobronchial valve treatment on diaphragm mobility in patients with chronic obstructive pulmonary disease COPD who experience breathlessness due to lung hyperinflation. This observational study aims to understand if diaphragm movement improves after valve treatment, its relationship with symptoms, lung function, and physical ability, and whether ultrasound right after treatment can predict patient benefit. Participants in this study are patients with severe emphysema undergoing treatment by insertion of one-way endobronchial valves into the bronchial system. These valves allow excess air to escape, reducing lung hyperinflation and potentially improving breathing. The study involves ultrasound examinations of the diaphragm before the procedure, one day after, and 90 days after valve insertion, alongside the collection of lung function tests from routine control visits. During their participation, patients will receive diaphragm ultrasound scans at three time points and have lung function tests including forced expiratory volume, vital capacity, lung volume, and diffusion capacity measured before and 90 days post-procedure. Additional assessments include a 6-minute walking test, lung X-rays to check for atelectasis, and questionnaires about breathlessness and COPD symptoms. The study will monitor changes over three months to evaluate diaphragm function and clinical outcomes following endobronchial valve treatment.

The Effect of Treatment of Emphysema With Endobronchial Valves on the Diaphragm Mobility