Study of How a 4-Week Ketogenic Diet Affects Brain Function and Alcohol Effects in Adults Ages 21 to 50

What this Trial Is About

Researchers are studying how a ketogenic diet affects brain function and the immediate effects of alcohol consumption. The study focuses on adults aged 21 to 50 who consume at least two alcoholic drinks on a single day in the month before joining. The goal is to understand changes in brain chemistry and alcohol tolerance while on the diet. Participants will follow a ketogenic diet for about four weeks, receiving all meals from a commercial service delivered weekly. There are three lab visits before starting the diet, around two weeks after starting, and after four weeks on the diet. During these visits, participants undergo alcohol tolerance tests, blood draws, and brain MRI scans to measure brain metabolites and neurotransmitters. Daily urine ketone tests and weekly check-in calls will monitor diet adherence and participant health. Throughout the study, participants provide urine and blood samples and complete cognitive and motor tasks following alcohol intake. The brain MRI is performed twice to capture detailed brain images and measure specific chemicals related to energy metabolism. Safety checks, vital signs, and questionnaires about mood and substance use are regularly collected. The total participation spans approximately one month with structured visits and daily monitoring.

Effects of Ketogenic Diet on Alcohol Intoxication