Study of Negative vs Positive Pressure Ventilation Effects on Heart Function After Durable Left Ventricular Assist Device Implantation

What this Trial Is About

This trial focuses on patients who have undergone implantation of a durable left ventricular assist device LVAD and are being monitored using a pulmonary artery catheter. The study aims to compare the effects of two different ventilation methods on heart function, particularly the right ventricle. Researchers are evaluating hemodynamic changes between extra thoracic negative pressure ventilation and traditional intrathoracic positive pressure ventilation in this patient group. Participants will first receive ventilation using negative pressure ventilation for 15 minutes, followed by ventilation with positive pressure ventilation. Both ventilation modes are applied sequentially to each participant while hemodynamic parameters are measured. The study does not include a placebo or control group but compares the two ventilation techniques within the same individuals. During the study, participants will be closely monitored using a pulmonary artery catheter to assess right ventricular function and other hemodynamic changes. The main outcome measure is the right ventricular stroke work index RVSWI recorded during one minute of ventilation. The total duration of the study participation is dependent on the ventilation period and monitoring immediately after LVAD implantation. Safety and stability of participants are carefully observed throughout the procedure.

Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Implantation of a Left Ventricular Assist Device.