Actively Recruiting
Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease
Led by University of Minnesota · Updated on 2026-02-13
75
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
Sponsors
U
University of Minnesota
Lead Sponsor
P
Parkinson's Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is designed to better understand the mechanisms contributing to impaired activation of leg muscles in people with Parkinson's disease (PD) and to test if stimulation of a nerve at the neck can improve muscle activation, walking and balance.
CONDITIONS
Official Title
Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of idiopathic Parkinson's disease
- On stable medication for at least the past month and expected to remain stable for the next 3 months
- Able to walk without an assistive device for more than 50 meters
- Control group matched by age (±3 years) and sex to the Parkinson's group
- Control group able to walk without an assistive device for more than 50 meters
You will not qualify if you...
- Unable to provide informed consent
- History of significant neurological disorders other than Parkinson's disease
- History of stroke, traumatic brain injury, brain tumor, intracranial aneurysm, hemorrhage, or atypical parkinsonian disorder
- Severe orthopedic or musculoskeletal problems affecting gait
- Pregnant or possibly pregnant women
- Insufficient understanding of English
- History of substance abuse within the past 2 years
- Pain or skin problems at the stimulation site
- Previous neck surgery or abnormal anatomy at stimulation site
- Severe cardiovascular disease or abnormal heart rhythms
- Uncontrolled blood pressure or heart rate issues
- Previous vagotomy surgery
- Presence of metallic implants or electronic medical devices near stimulation site
- History of fainting or seizures within the last 2 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Movement Disorders Laboratory
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
P
Principal Investigator
CONTACT
K
Kristin Garland
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
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