Comparing Standard and Restricted Fluid Therapy Guided by Electrical Cardiometry During Robotic Prostate Surgery to Improve Tissue Perfusion

What this Trial Is About

This research aims to explore the best fluid therapy approach during robotic-assisted prostate surgery to improve tissue perfusion and reduce complications such as wound healing delays or acute kidney injury. The study compares standard liberal versus restricted fluid intake guided by electrical cardiometry, a non-invasive method measuring stroke volume variation to optimize fluid management during surgery. Participants will be randomly assigned to one of two groups the Liberal Fluid Therapy Group, receiving a higher rate of lactated ringer fluids with adjustments based on blood pressure, and the Restricted Fluid Therapy Group, receiving lower fluid amounts with boluses guided by stroke volume variation targets. Both groups include protocols for managing persistent low blood pressure using medications. The study uses a parallel design with double masking to compare these fluid management strategies. During the study, participants will undergo robotic prostate surgery with fluid therapy guided by electrical cardiometry. Researchers will monitor tissue perfusion through serum lactate levels and creatinine clearance, focusing on changes within 24 hours post-surgery. The trial will assess outcomes related to fluid management effectiveness and safety in this surgical setting, with study completion expected in December 2026.

Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic Prostaectomy