End-expiratory Trans-pulmonary Pressure Guided PEEP Titration in Patients With Pulmonary Fibrosis and UIP Pattern Undergoing Mechanical Ventilation

What this Trial Is About

This research aims to document the effects of adjusting positive end-expiratory pressure (PEEP) guided by end-expiratory trans-pulmonary pressure on lung mechanics in patients with pulmonary fibrosis and usual interstitial pneumonia (UIP) pattern who require mechanical ventilation for acute respiratory failure. Patients with these conditions often have poor outcomes, possibly due to the interaction between their fibrotic lungs and the mechanical ventilation stress. The study compares these patients to those with acute respiratory distress syndrome (ARDS) undergoing similar ventilation. The study observes patients with pulmonary fibrosis and UIP pattern and patients with ARDS, both groups undergoing mechanical ventilation for acute respiratory failure. It focuses on the PEEP titration maneuver based on trans-pulmonary pressure to potentially improve lung mechanics and oxygenation. No specific interventions are assigned since this is an observational study. Participants will be closely monitored with measurements including lung elastance and the P/F ratio at 2 hours after the PEEP titration trial. The study evaluates lung mechanics changes and oxygenation without altering standard care practices. The observational period and follow-up are limited to these immediate measurements, with no long-term interventions or treatments applied.

End-expiratory Trans-pulmonary Pressure Guided PEEP Titration in Patients With Pulmonary Fibrosis and UIP Pattern Undergoing Mechanical Ventilation