Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder.
Jana Zweerings, Pegah Sarkheil, Micha Keller...
https://pubmed.ncbi.nlm.nih.gov/33395974Actively Recruiting
Led by University of Electronic Science and Technology of China · Updated on 2025-03-27
50
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to study how real-time functional near-infrared spectroscopy (fNIRS) neurofeedback training combined with cognitive reappraisal strategies can help healthy individuals regulate negative emotions. The study focuses on increasing brain activity in the prefrontal cortex (PFC) to improve emotion regulation during exposure to negative stimuli and stressful situations. The approach addresses the growing need for innovative methods to reduce stress-related disorders like depression and anxiety. Participants will be randomly assigned to one of two groups: a real fNIRS neurofeedback training group or a sham feedback group. Both groups will receive training to use cognitive reappraisal strategies while viewing negative images. Real-time brain activity in the target PFC region will be monitored and used to provide visual feedback in the experimental group, while the sham group will receive prerecorded feedback. The study is double-blinded, so neither participants nor experimenters will know group assignments. During the study, participants will complete questionnaires before and after training and undergo a cold-pressor test to assess stress and pain regulation. Researchers will measure the success of neurofeedback based on brain activity within 35 minutes of training, and evaluate effects on emotion and pain regulation during the 50-60 minute post-training period. The trial includes detailed monitoring of brain function and behavioral responses to understand how these methods influence emotion control.
CONDITIONS
Enhancing Emotion Regulation Through Functional Near-infrared Spectroscopy (fNIRS)-Informed Real-time Neurofeedback
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You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 hour
Participants undergo training using real-time fNIRS neurofeedback or sham feedback combined with cognitive reappraisal strategies to regulate negative emotions.
1 training session (in-person)
Total: 1 location
1
The Hong Kong Jockey Club Building For Interdisciplinary Research, 5 Sassoon Rd, Sandy Bay
Hong Kong, Hong Kong
Actively Recruiting
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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