Actively Recruiting

Phase Not Applicable
Age: 18Years - 30Years
All Genders
Healthy Volunteers
ID06866028

Enhancing Emotion Regulation Through fNIRS-informed Real-time Neurofeedback for Healthy Adults Aged 18 to 30

Led by University of Electronic Science and Technology of China · Updated on 2025-03-27

50

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to study how real-time functional near-infrared spectroscopy (fNIRS) neurofeedback training combined with cognitive reappraisal strategies can help healthy individuals regulate negative emotions. The study focuses on increasing brain activity in the prefrontal cortex (PFC) to improve emotion regulation during exposure to negative stimuli and stressful situations. The approach addresses the growing need for innovative methods to reduce stress-related disorders like depression and anxiety. Participants will be randomly assigned to one of two groups: a real fNIRS neurofeedback training group or a sham feedback group. Both groups will receive training to use cognitive reappraisal strategies while viewing negative images. Real-time brain activity in the target PFC region will be monitored and used to provide visual feedback in the experimental group, while the sham group will receive prerecorded feedback. The study is double-blinded, so neither participants nor experimenters will know group assignments. During the study, participants will complete questionnaires before and after training and undergo a cold-pressor test to assess stress and pain regulation. Researchers will measure the success of neurofeedback based on brain activity within 35 minutes of training, and evaluate effects on emotion and pain regulation during the 50-60 minute post-training period. The trial includes detailed monitoring of brain function and behavioral responses to understand how these methods influence emotion control.

CONDITIONS

Brief Title

Enhancing Emotion Regulation Through Functional Near-infrared Spectroscopy (fNIRS)-Informed Real-time Neurofeedback

Who Can Participate

Age: 18Years - 30Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Normal or corrected-to-normal vision
  • Right-handed
  • Beck Depression Inventory (BDI-II) score below 29, indicating no clinically significant depression
  • Age between 18 and 30 years
  • Ability to participate as a healthy volunteer
Not Eligible

You will not qualify if you...

  • Current or history of mental health conditions
  • Current or history of chronic pain
  • Cardiovascular disorders
  • Raynaud's phenomenon
  • History of fainting or seizures
  • Wounds on the hand or arm
  • Frequent use of alcohol or nicotine

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

fNIRS Neurofeedback Training

Duration - Approximately 1 hour

Participants undergo training using real-time fNIRS neurofeedback or sham feedback combined with cognitive reappraisal strategies to regulate negative emotions.

1 training session (in-person)

Trial Site Locations

Total: 1 location

1

The Hong Kong Jockey Club Building For Interdisciplinary Research, 5 Sassoon Rd, Sandy Bay

Hong Kong, Hong Kong

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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Published Research Related To This Trial

Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder.

Jana Zweerings, Pegah Sarkheil, Micha Keller...

https://pubmed.ncbi.nlm.nih.gov/33395974

Neuroimaging cognitive reappraisal in clinical populations to define neural targets for enhancing emotion regulation. A systematic review.

Anna Zilverstand, Muhammad A Parvaz, Rita Z Goldstein

https://pubmed.ncbi.nlm.nih.gov/27288319

Putamen volume predicts real-time fMRI neurofeedback learning success across paradigms and neurofeedback target regions.

Zhiying Zhao, Shuxia Yao, Jana Zweerings...

https://pubmed.ncbi.nlm.nih.gov/33400306

Voluntary control of anterior insula and its functional connections is feedback-independent and increases pain empathy.

Shuxia Yao, Benjamin Becker, Yayuan Geng...

https://pubmed.ncbi.nlm.nih.gov/26899786

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic.

COVID-19 Mental Disorders Collaborators

https://pubmed.ncbi.nlm.nih.gov/34634250

fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation.

Micha Keller, Jana Zweerings, Martin Klasen...

https://pubmed.ncbi.nlm.nih.gov/34497546