Actively Recruiting
Evaluating Pumpkin Seed Oil Extract Supplementation on Bladder Function in Women with Overactive Bladder
Led by Northwestern University · Updated on 2026-04-23
40
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how taking pumpkin seed oil extract affects bladder function in women with overactive bladder (OAB) in the United States. The study aims to measure changes in bladder symptoms using validated surveys, focusing on patient-reported outcomes such as urinary frequency, urgency, and pelvic floor control. This pilot study seeks to better understand the impact of this dietary supplement on bladder health in a diverse U.S. population. Participants will receive a bottle of pumpkin seed oil extract (1000mg per pill) to take one pill daily for 12 weeks. They will start the supplement on the day they receive it and continue for the full study period. Patients are advised not to start new medications or supplements and not to share the pumpkin seed oil during the study. Follow-up questionnaires will be completed at 4 and 12 weeks to assess changes in bladder function, pelvic floor control, and supplement adherence. During the study, participants will complete several surveys including the Lower Urinary Tract Dysfunction Network Symptom Index-10 (LURN-SI), Pelvic Pain and Urgency/Frequency (PUF) questionnaire, and Medication Adherence Questionnaire (MAQ). Researchers will monitor patient responses to assess bladder symptoms and willingness to continue the supplement. Data will be securely stored and analyzed after the 12-week period. Participants are also advised to follow up with their urogynecologist if no improvement occurs after 3 months.
CONDITIONS
Brief Title
Evaluating Pumpkin Seed Oil Extract Supplementation on Bladder Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients evaluated at Northwestern's IPHP reporting overactive bladder symptoms (urinary urgency, frequency over 8 times daily or nocturia, with or without urgency urinary incontinence)
- Willingness to use a dietary supplement
- Agree not to start new behavioral, medication, or procedural treatments for 12 weeks following pumpkin seed oil extract initiation
You will not qualify if you...
- Use of other supplements containing pumpkin seed oil
- Stage 3 or greater pelvic organ prolapse
- Urinary post-void residual volume of 150cc or more
- Culture-proven urinary tract infection at study enrollment
- Recurrent urinary tract infection
- Neurogenic bladder
- Abdominal or pelvic malignancy
- Initiation of new overactive bladder medications or supplements during the study period or in the 3 months before enrollment
- History of pelvic surgery in the past 12 months for prolapse or urinary/fecal incontinence
- Primary language not English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) to assess symptoms and eligibility
Duration - 1 day
Participants complete initial questionnaires and receive the pumpkin seed oil extract supplement to start daily use.
1 baseline visit (in-person)
Duration - 12 weeks
Participants take one pill of pumpkin seed oil extract daily for 12 weeks while completing follow-up questionnaires to assess bladder function and supplement adherence.
Questionnaires completed at 4 weeks and 12 weeks (remote via electronic device)
Trial Site Locations
Total: 1 location
1
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
J
Julia Geynisman-Tan, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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