Actively Recruiting
Exercise in Patients With Hypermobile Joints and Knee Pain
Led by University of Southern Denmark · Updated on 2026-04-29
90
Participants Needed
2
Research Sites
197 weeks
Total Duration
On this page
Sponsors
U
University of Southern Denmark
Lead Sponsor
I
Independent Research Fund Denmark
Collaborating Sponsor
AI-Summary
What this Trial Is About
Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.
CONDITIONS
Official Title
Exercise in Patients With Hypermobile Joints and Knee Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persistent knee pain for 23C 3 months (self-reported)
- Knee pain 23C 30mm during the last week on a 0-100 mm visual analogue scale (self-reported)
- Generalised joint hypermobility assessed with the Five-Part Hypermobility Questionnaire (positive 23C 2/5) (self-reported)
- Local knee joint hypermobility with passive hyperextension > 10 degrees confirmed in standing and supine positions (objectively measured)
You will not qualify if you...
- Diagnosed with patellar tendinopathy
- Pregnancy or childbirth within the past year
- Knee surgery within the past year
- Participation in regular structured resistance training within the past six months
- Inability to speak and understand Danish
- All types of Ehlers-Danlos syndrome
- Other heritable connective tissue disorders such as Marfan syndrome, osteogenesis imperfecta, Loeys-Dietz syndrome, Stickler syndrome, skeletal dysplasias
- Autoimmune rheumatic connective tissue disorders such as lupus, rheumatoid arthritis
- Chromosomal conditions such as Fragile X syndrome, Kabuki syndrome, Down syndrome
- Neuromuscular disorders causing joint instability such as multiple sclerosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Physiotherapy Clinics Region of Southern Denmark
Odense, Fyn, Denmark, 5000
Actively Recruiting
2
University of Southern Denmark
Odense, Fyn, Denmark, 5230
Actively Recruiting
Research Team
B
Behnam Liaghat, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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