Study of Extracellular Vesicle Protein Markers to Detect Rejection in Heart Transplant Patients

What this Trial Is About

Researchers are studying patients who are either on the waiting list for heart transplantation or have recently undergone heart transplant surgery. The study aims to analyze protein profiles derived from extracellular vesicles EV during the first 15 months after transplantation. The goal is to find specific EV protein markers or patterns that can help detect acute cardiac allograft rejection early and reliably. Additionally, the study will explore changes in EV protein profiles over time after surgery and look for connections between these protein markers and imaging results. Participants include those actively listed for heart transplantation or hospitalized after their transplant surgery. The study involves monitoring and collecting data related to EV-derived proteins over 15 months post-transplant. There are no study drugs or interventions instead, this is an observational study tracking biological markers and imaging findings in the early post-operative period. During the study, participants will undergo evaluations to measure EV protein markers and imaging tests. Researchers will identify biomarkers linked to biopsy-proven acute cellular or antibody-mediated cardiac allograft rejection. The study duration for each participant is 15 months, during which their biological and imaging data will be monitored. Consent and capacity to participate are required, and safety and compliance will be observed throughout the follow-up period.

Extracellular Vesicles for Rejection Monitoring in Cardiac Transplantation