Study of Low-Field MRI-Guided Adaptive Radiation Therapy for Localized Prostate Cancer in Men with Bilateral Hip Prostheses

What this Trial Is About

Hip replacements and prostate cancer are both common conditions in the aging male population. This research investigates the use of low-field magnetic resonance MR-informed adaptive marker-less stereotactic body radiotherapy SBRT for treating localized prostate cancer in men with bilateral hip prostheses. The study addresses challenges caused by metallic hip implants that interfere with imaging quality during radiotherapy planning and delivery, aiming to improve treatment precision for this specific patient group. Participants will receive a specialized SBRT treatment using a two-room system that includes a low-field MRI scanner and a C-arm linear accelerator. This setup involves transferring patients on an air-bearing shuttle system between the MR device and the treatment machine without moving the patients position, reducing image artifacts caused by metal implants. The study evaluates the feasibility of this approach for definitive prostate cancer treatment. During the study, participants will be monitored for treatment toxicity, image quality, wellbeing, and physician confidence. Assessments will occur from enrollment through treatment and up to five years afterward to track long-term effects. The primary outcome focuses on the success of the MR-informed adaptive SBRT, with secondary measures including patient comfort and treatment safety. Participation involves imaging, treatment sessions, and ongoing follow-up to ensure comprehensive evaluation.

Feasibility of MR-Informed Adaptive Marker-less SBRT in Patients With Bilateral Hip Prostheses Undergoing SBRT for Localized Prostate Cancer