Study of Forearm Muscle Glucose and Amino Acid Metabolism Changes After 2 Days of Forearm Immobilization in Adults With or Without Type 2 Diabetes

What this Trial Is About

This research aims to study the effects of short-term forearm immobilization on forearm muscle glucose uptake and amino acid metabolism in people with type 2 diabetes compared to those without diabetes. The goal is to understand how local physical inactivity impacts muscle metabolism in these two groups. The study is conducted by Wageningen University and focuses on basic science related to muscle and metabolic responses. Participants will undergo two days of forearm immobilization to create a model of local inactivity. During this time, standardized meals will be consumed, and muscle metabolism will be measured through arteriovenous balance assessments combined with stable isotope tracer infusions. These measurements will track muscle glucose uptake and amino acid balance, uptake, and release before, during, and after immobilization. Throughout the study, participants will have multiple assessments including blood sampling, muscle metabolism evaluations, and meal monitoring over a 48-hour period. Researchers will measure changes in forearm muscle glucose uptake and amino acid kinetics along with whole-body substrate oxidation at regular intervals. The total study duration includes the immobilization period and related metabolic assessments, with ongoing monitoring of muscle metabolic changes.

Forearm Immobilization in T2D