Study of Respiratory Syncytial Virus Infection Rates, Genotypes, and Disease Severity in Hospitalized Older Adults in Vietnam

What this Trial Is About

Researchers are investigating the proportion and characteristics of Respiratory Syncytial Virus RSV infections in adults aged 60 and older who are hospitalized with acute respiratory infections or worsening cardiopulmonary disease. This observational, prospective, multicenter study aims to better understand RSVs impact, including genotype distribution, viral load, co-infections, disease severity, and healthcare use in this elderly population in Vietnam. The study will enroll 1000 participants at two hospitals, where standard care will be given without any experimental treatment. Within 24 hours of consent, nasal and sputum samples will be collected for testing RSV, influenza, and COVID-19 using PCR methods. A subset of samples will undergo advanced genetic sequencing to identify virus types and other pathogens. Data on clinical presentation, treatment, and outcomes will be gathered during hospitalization, with severity assessed by questionnaires and clinical scores. After discharge, participants will be followed by phone for three months to monitor health status and healthcare use such as readmissions and outpatient visits. Researchers will collect detailed demographic, clinical, and laboratory data to analyze factors linked to severe RSV infection. Ethical standards will be maintained, and patient data will be securely handled. The study will provide valuable information to guide RSV prevention and vaccination efforts for older adults in Vietnam.

Genotype and Disease Burden of RSV in Older Vietnamese Adults (RSV: Respiratory Syncytial Virus )