Actively Recruiting
Halt Aging in Survivors of Blood Cancers: the HALTAging-1 Study
Led by University of Nebraska · Updated on 2026-05-18
180
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Older survivors of blood cancer face a higher risk of accelerated biological aging, which can lead to multiple age-related health issues. This research is a Phase 2 randomized control trial designed to test how behavioral and exercise programs affect various health outcomes for these older survivors. The study aims to fill important knowledge gaps about the amount and duration of exercise needed to slow aging in this group. Participants will be randomly assigned to one of two groups. One group will take part in a virtually supervised moderate-intensity aerobic exercise program combined with behavioral coaching to help improve adherence. The other group will have access to a virtual exercise platform and educational sessions but will not receive behavioral coaching. The study will evaluate these approaches over a 6- to 12-month period. During the study, participants' adherence to the exercise regimen will be monitored at 6 and 12 months after enrollment. Researchers will also assess physical function using a 6-minute walk test at 6 months. The trial involves virtual exercise sessions, educational activities, and behavioral support to promote sustained physical activity. The total study duration allows for monitoring long-term exercise adherence and functional outcomes in older blood cancer survivors.
CONDITIONS
Brief Title
Halt Aging in Survivors of Blood Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 years or older
- History of hematological malignancy
- Ability and willingness to give informed consent
You will not qualify if you...
- Receiving intensive induction or consolidation chemotherapy
- Neurodegenerative disease, recent stroke, or uncontrolled psychotic disorders impairing participation
- Clinical evidence of decompensated heart failure, unstable angina, or orthopedic/neuromuscular disorders limiting safe aerobic exercise
- Cardiopulmonary exercise test results that preclude safe exercise (e.g., life-threatening arrhythmia, balance difficulties, peak VO2 <10 ml/kg/min)
- Estimated life expectancy less than 6 months
- Self-reported pregnancy or possibility of pregnancy
- No plan to follow up at the participating center
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 months from enrollment
Participants engage in virtually supervised moderate-intensity aerobic exercise and behavioral coaching or access a virtual exercise platform to improve physical function and exercise adherence.
Regular virtual sessions throughout the study duration
Trial Site Locations
Total: 1 location
1
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68008
Actively Recruiting
Research Team
T
Taylor Johnson
I
IIT OFFICE
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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