Actively Recruiting
Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences
Led by University of Leeds · Updated on 2025-02-28
600
Participants Needed
1
Research Sites
257 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This will be an observational study to explore differences in pathophysiology between groups of people with and without heart failure (HF) (reduced and preserved ejection fraction) and with and without diabetes mellitus (DM) with a particular focus on cross-talk (fat, muscle, vascular tissue and the heart). The investigators will invite 600 people to partcipate (100 with HFrEF+DM, 100 with HFpEF+DM, 100 with HFpEF-DM, 100 with HFrEF-DM, 100 with DM, 100 without either HR or DM). Special heart scans, exercise testing, blood testing, testing of the automatic nervous system will be performed and in some, samples of fat and muscle and endothelial cells will be collected. These data will be used to create a cohort of well phenotyped patients with a variety of comprehensively collected clinical information, a cell atlas, and a comprehensive assessment of metabolomics, proeomics and cross-talk in between tissues, allowing comparisons between each group.
CONDITIONS
Official Title
Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age >18 years
- Ability to provide written informed consent
- Persons who are legally competent and mentally able to follow the instructions of the study staff
You will not qualify if you...
- Anemia with hemoglobin less than 8 mg/dl
- Acute infectious diseases such as pneumonia
- Heart failure caused by sepsis
- Acute myocardial ischemia shown by angina or ECG changes under stress
- Acute liver or kidney failure or severe COPD with FEV1 less than 1.0
- Pregnant or breastfeeding women
- People institutionalized by official or court orders
- People dependent on or employed by the sponsor or investigator
- Use of investigational drugs within 30 days before study start
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Leeds Teaching Hospitals NHS Trust
Leeds, West Yorkshire, United Kingdom, LS16 5AR
Actively Recruiting
Research Team
K
Klaus Witte, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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