Exploring How Diabetes and Heart Failure Affect the Bodys Tissues and Heart Function

What this Trial Is About

Researchers are exploring differences in heart function and metabolism in people with and without heart failure both reduced and preserved ejection fraction and with and without type 2 diabetes. The study focuses on how fat, muscle, blood vessels, and the heart interact. This observational study aims to better understand how diabetes and heart failure work together at a cellular level to affect health, which could help guide future treatments. The study is conducted by the University of Leeds and involves a detailed examination of various patient groups. Participants are divided into six groups based on their heart failure and diabetes status those with reduced ejection fraction heart failure with or without diabetes, those with preserved ejection fraction heart failure with or without diabetes, people with diabetes only, and healthy controls without either condition. The study includes heart ultrasounds, exercise tests, lung and muscle strength assessments, blood tests, glucose monitoring, and in some cases tissue samples and MRI scans. Data collection is comprehensive, including metabolomics and cell studies. Participants will undergo detailed testing at the start, including scans, blood sampling, and physical assessments. After initial testing, they will be followed annually through their medical records for up to ten years to track health outcomes. The study measures long-term effects and aims to link cellular and metabolic findings with clinical results. Tissue and blood samples will be stored and analyzed to identify how diabetes affects heart failure progression, supporting the development of targeted therapies.

Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences