Actively Recruiting
HELIOS Advanced: Human Oocyte Illumination to Enhance Development
Led by Columbia University · Updated on 2026-03-25
270
Participants Needed
1
Research Sites
114 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well. This makes it harder for eggs and embryos to develop normally. One possible way to help is with a gentle light treatment called photobiomodulation (PBM). This uses a special type of red light that boosts energy production in cells and helps them stay healthy. This study will test whether adding this light treatment during in vitro fertilization (IVF) can improve embryo growth and pregnancy outcomes.
CONDITIONS
Official Title
HELIOS Advanced: Human Oocyte Illumination to Enhance Development
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female age between 18 and 48 years at the time of the IVF/ICSI cycle
- Undergoing blastocyst culture
- Using own oocytes
- Has at least two oocytes available for randomization
- Consenting to oocyte level randomization
- Plans to transfer a euploid embryo within 6 months
You will not qualify if you...
- Use of donor oocytes or gestational carrier
- Concurrent experimental laboratory interventions outside of protocol
- Refusal of randomization or request for non-standard handling
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Columbia University Fertility Center
New York, New York, United States, 10019
Actively Recruiting
Research Team
S
Samuel Zev Williams, MD, PhD
CONTACT
L
Laura C Gemmell, MD, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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