ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.
Ingrid E Scheffer, Samuel Berkovic, Giuseppe Capovilla...
https://pubmed.ncbi.nlm.nih.gov/28276062Actively Recruiting
Phase Not Applicable
All Genders
ID06550726
High-resolution Multi-parametric Magnetic Resonance Imaging for Focal Epilepsy
Led by Chinese University of Hong Kong · Updated on 2026-04-03
66
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to improve the detection of subtle brain lesions that cause focal epilepsy, a condition where seizures start in a specific brain area. Patients with structural lesions tend to have more frequent seizures, and sometimes standard MRI scans do not reveal these lesions. The study focuses on using advanced MRI techniques, especially T1-weighted inversion recovery sequences, to better identify these lesions in patients whose initial MRI showed no findings. Participants will undergo MRI scanning using a 3T MRI machine with specialized high-resolution sequences. These include 2D T1-weighted inversion recovery sequences, 3D FLAIR whole brain imaging, and 3D T1-weighted Sagittal MPRAGE sequences. Additional sequences may be used for clinical planning as needed. This dedicated MRI protocol is expected to enhance lesion detection compared to standard imaging. During the study, patients will have their MRI scans assessed for accuracy in diagnosing focal epilepsy lesions, typically within one day of scanning. Participants must provide informed consent before the MRI, and those under 18 will have consent obtained from a guardian. The main measure is how well the high-resolution MRI detects lesions that were missed on previous scans. The study will monitor patient cooperation and safety throughout the imaging process, with total involvement mainly focused on the MRI procedure.
CONDITIONS
Brief Title
High-resolution Multi-parametric Magnetic Resonance Imaging for Focal Epilepsy
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosis of drug-resistant focal epilepsy with a probable site identified by at least two of the following: clinical symptoms, EEG pointing to a specific site, or positive ictal brain scintigraphy with SPECT-CT correlation
- Previous MRI scan tailored for epilepsy that did not reveal a lesion
- Able to provide informed consent for MRI examination, or guardian consent if under 18
You will not qualify if you...
- Contraindications to MRI, such as MRI-incompatible metallic implants
- Inability to cooperate during MRI scanning
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - 1 day
Participants undergo high-resolution MRI scanning using dedicated sequences to detect subtle brain lesions related to focal epilepsy.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Gerald Choa MRI Center
Hong Kong, Hong Kong
Actively Recruiting
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Research Team
H
Hanson Leung, MBBS (HK)
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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Published Research Related To This Trial
Recommendations for the use of structural magnetic resonance imaging in the care of patients with epilepsy: A consensus report from the International League Against Epilepsy Neuroimaging Task Force.
Andrea Bernasconi, Fernando Cendes, William H Theodore...
https://pubmed.ncbi.nlm.nih.gov/31135062Evidence-based guideline: Management of an unprovoked first seizure in adults: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society.
Allan Krumholz, Samuel Wiebe, Gary S Gronseth...
https://pubmed.ncbi.nlm.nih.gov/25901057Thin isotropic FLAIR MR images at 1.5T increase the yield of focal cortical dysplasia transmantle sign detection in frontal lobe epilepsy.
Vasileios Kokkinos, Alexandros Kallifatidis, Eftychia Z Kapsalaki...
https://pubmed.ncbi.nlm.nih.gov/282798923T MRI improves the detection of transmantle sign in type 2 focal cortical dysplasia.
Charles Mellerio, Marc-Antoine Labeyrie, Francine Chassoux...
https://pubmed.ncbi.nlm.nih.gov/24237393Phase-sensitive T1 inversion recovery imaging: a time-efficient interleaved technique for improved tissue contrast in neuroimaging.
Ping Hou, Khader M Hasan, Clark W Sitton...
https://pubmed.ncbi.nlm.nih.gov/15956512