Shaping of object representations in the human medial temporal lobe based on temporal regularities.
Anna C Schapiro, Lauren V Kustner, Nicholas B Turk-Browne
https://pubmed.ncbi.nlm.nih.gov/22885059Actively Recruiting
Phase Not Applicable
Age: 18Years - 35Years
All Genders
Healthy Volunteers
ID05910762
Learning Novel Structure Across Time and Sleep
Led by University of Pennsylvania · Updated on 2025-08-01
105
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how humans learn new structured information by studying the brain's hippocampus and its role in quickly recognizing patterns and storing knowledge for future use. This research aims to clarify how people integrate information across experiences and how memories change over time, including the impact of sleep on memory consolidation. The study uses advanced brain imaging and sleep monitoring to explore competing theories about how memories are formed and stored.
CONDITIONS
Brief Title
Human Learning of New Structured Information Across Time and Sleep
Who Can Participate
Age: 18Years - 35Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Between 18 and 35 years of age
- Not a member of a vulnerable population
- Normal or corrected-to-normal vision
- Normal hearing
- Able to speak English fluently
- No prior history of major psychiatric or neurological disorders (for MRI parts)
- Not currently taking any antidepressants or sedatives (for MRI parts)
- No known neurological disorders (for EEG parts)
You will not qualify if you...
- Presence of MR contraindications such as non-removable biomedical devices or metal in or on the body (for MRI parts)
- Claustrophobia (for MRI parts)
- Pregnancy (excluded from neuroimaging parts)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Outpatient Treatment
Duration - Single study session spanning 4 to 5 hours
Participants engage in behavioral learning tasks involving associative inference and category learning, with memory assessed behaviorally and neural representations assessed using fMRI or EEG depending on the study arm.
1 visit (in-person)
Outpatient Treatment
Duration - Single session with nap and memory testing
Participants sleep while EEG is recorded and memory is assessed before and after the nap; spoken names are played during sleep to encourage memory reactivation.
1 visit (in-person)
Outpatient Treatment
Duration - Second session spanning 1 to 2 hours about one week after initial session
Participants return approximately one week later for a second session to assess changes in neural representations and memory consolidation using fMRI and behavioral measures.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
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Research Team
A
Anna C Schapiro, PhD
R
Rishi Krishnamurthy, BA
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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Published Research Related To This Trial
Statistical learning of temporal community structure in the hippocampus.
Anna C Schapiro, Nicholas B Turk-Browne, Kenneth A Norman...
https://pubmed.ncbi.nlm.nih.gov/26332666The necessity of the medial temporal lobe for statistical learning.
Anna C Schapiro, Emma Gregory, Barbara Landau...
https://pubmed.ncbi.nlm.nih.gov/24456393The Necessity of the Hippocampus for Statistical Learning.
Natalie V Covington, Sarah Brown-Schmidt, Melissa C Duff
https://pubmed.ncbi.nlm.nih.gov/29308986Memory integration: neural mechanisms and implications for behavior.
Margaret L Schlichting, Alison R Preston
https://pubmed.ncbi.nlm.nih.gov/25750931Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory.
James L McClelland, Bruce L McNaughton, Randall C O'Reilly
https://pubmed.ncbi.nlm.nih.gov/7624455Complementary learning systems within the hippocampus: a neural network modelling approach to reconciling episodic memory with statistical learning.
Anna C Schapiro, Nicholas B Turk-Browne, Matthew M Botvinick...
https://pubmed.ncbi.nlm.nih.gov/27872368Modeling hippocampal and neocortical contributions to recognition memory: a complementary-learning-systems approach.
Kenneth A Norman, Randall C O'Reilly
https://pubmed.ncbi.nlm.nih.gov/14599236Building integrated representations through interleaved learning.
Zhenglong Zhou, Dhairyya Singh, Marlie C Tandoc...
https://pubmed.ncbi.nlm.nih.gov/37227843Generalization through the recurrent interaction of episodic memories: a model of the hippocampal system.
Dharshan Kumaran, James L McClelland
https://pubmed.ncbi.nlm.nih.gov/22775499