Hyperbaric Oxygen Therapy to Improve Sperm Count in Men with Oligospermia and Infertility

What this Trial Is About

Infertility affects about 12% of couples trying to conceive, and male factors like oligospermialow sperm countare a common cause. This study aims to explore whether hyperbaric oxygen therapy HBOT can improve sperm count in men diagnosed with idiopathic oligospermia. It focuses on how HBOT may affect sperm quality through mechanisms involving mitochondria and telomeres, which are important for sperm function and genomic stability. The treatment involves 60 daily sessions of HBOT over three months, with five sessions each week. During each 90-minute session, participants breathe 100% oxygen at 2 atmospheres absolute pressure ATA using a mask, with 5-minute air breaks every 20 minutes. All eligible men will receive this therapy in a multi-place chamber, and there are no placebo or control groups. Participants will be evaluated four times before treatment, after 40 sessions, at the end of the treatment period, and 60 days post-treatment. Assessments include sperm analysis and measuring telomere length in sperm and lymphocytes. The main outcome is sperm count at baseline and three months, with additional assessments of sperm morphology, motility, and telomere length up to nine months. The study will monitor safety and treatment effects throughout the period.

Hyperbaric Oxygen Therapy for Men Suffering From Infertility Due to Oligospermia.