Study of Immune Cells in Lung Cancer, Sarcoidosis, COPD, and Related Lung Conditions Including Use of Samples from Orthopedic Surgery Patients and Healthy Volunteers

What this Trial Is About

Researchers are investigating the role of immune system cells in lung diseases, including lung cancer, sarcoidosis, and chronic obstructive pulmonary disease COPD. The study aims to understand how these immune cells can both protect the body and sometimes contribute to cancer growth or ongoing lung inflammation. The research also seeks to explore why some patients do not respond or develop resistance to immunotherapy treatments, with the goal of improving personalized care in the future. Participants include groups such as patients with precancerous lung lesions, those diagnosed with lung cancer at any stage, individuals with chronic inflammatory lung diseases like sarcoidosis or COPD, healthy volunteers without lung disease, children and adolescents with chronic granulomatous disease, and adults undergoing orthopedic surgery who will provide bone marrow samples. The study involves collecting biological samples like peripheral blood, tumor tissue, lymph nodes, and bone marrow when available, to analyze immune cell types and their functions. No experimental treatments are given all medical care is independent of study participation. During the study, participants provide biological samples for immune profiling to help researchers study immune mechanisms related to disease progression and treatment responses. The primary outcome measured is progression-free survival over approximately seven years. Study participation includes regular monitoring without altering usual medical care. The study runs from February 2025 to February 2032, with a maximum participant age of 80 years.

Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease