Actively Recruiting
Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Led by Fondation Ophtalmologique Adolphe de Rothschild · Updated on 2026-01-05
82
Participants Needed
1
Research Sites
445 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities. Whether ongoing seizure activity contributes to network pathology is a matter of debate. This study intends to measure the impact of seizures on structural connectivity on a local and on a global level. In children examined with intracerebral electrodes to evaluate whether a surgical cure can be proposed, we combine intracerebral stereotactic electroencephalography (EEG) recordings with diffusion weighted imaging of white matter fibers. On the local level, the study will quantify the number of deficient connections in the seizure onset zone. On a global level, the study will compare the white matter fibers of the left and right hemisphere to probe whether physiological language lateralization is preserved.
CONDITIONS
Official Title
Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Drug resistant focal epilepsy
- Control patients without drug resistant focal epilepsy
You will not qualify if you...
- Severe mental retardation (IQ < 50)
- Lack of French-language skills
- Contraindications to MRI
- Bi-hemispherical epilepsy or epilepsy affecting multiple lobes
- Congenital pathology altering cerebral connectivity (for control patients)
- Parenchymal brain lesions (for control patients)
- Unilateral or bilateral blindness (for control patients)
- Unilateral or bilateral deafness (for control patients)
- Autistic disorders (for control patients)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondation Ophtalmologique A. de Rothschild
Paris, France
Actively Recruiting
Research Team
L
Laurence Salomon, MD PhD
CONTACT
V
Vera Dinkelacker, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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