Study of How Menstrual Cycles Affect Blood Sugar and Exercise in Women with Type 1 Diabetes Aged 18 to 45

What this Trial Is About

Researchers are studying how sex hormones, including the use of hormonal birth control and different menstrual cycle phases, affect blood sugar control in women with type 1 diabetes T1D. The study aims to understand patterns of glycemic variability across menstrual phases and how these impact responses to physical activity. It also seeks to test personalized adjustments to insulin dosing and food intake to reduce blood sugar fluctuations related to the menstrual cycle. Participants will first be observed for three months using continuous glucose monitoring CGM to track glucose levels and identify patterns tied to menstrual phases and exercise. Based on this data, personalized modifications to insulin dosing, carbohydrate intake, and glycemic control algorithms will be developed. Women will then be randomly assigned to either receive these personalized treatment adjustments or continue with their usual care for an additional three months. Throughout the study, participants will have their glucose time in range and glucose variability measured over the intervention period. Glucose levels before, during, and after exercise will also be monitored, along with patient-reported outcomes and responses to various exercise types. The study involves close monitoring of insulin dosing, food intake, and physical activity, aiming to improve glycemic control by tailoring treatment to menstrual cycle phases. The total duration includes a three-month observation followed by a three-month intervention or standard care period.

Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes