Evaluating How Propofol and Ketamine Affect Heart and Blood Pressure Stability During Intubation in Critically Ill ICU Patients

What this Trial Is About

Researchers are studying the effects of two drugs, propofol and ketamine, on the risk of cardiovascular collapse during the process of inducing anesthesia for endotracheal intubation in critically ill patients. The study focuses on how these drugs impact blood pressure and heart function since patients in critical care are at risk of severe drops in blood pressure or cardiac arrest during this procedure. The goal is to better understand which drug might help maintain heart stability in this vulnerable group. This observational study compares the incidence of cardiovascular collapse, defined as severe low blood pressure or cardiac arrest within the first 30 minutes after starting the drug, between patients given propofol or ketamine. It also examines related shock indices such as systolic and diastolic shock index, age-adjusted shock index, and modified shock index to assess the hemodynamic impact of each drug. The study does not involve randomization or treatment assignment but observes outcomes based on the induction agent used. Participants are critically ill adults over 18 years old who undergo intubation in the intensive care unit. Researchers monitor vital signs, including blood pressure and oxygen levels, and track any episodes of cardiovascular collapse or need for interventions like norepinephrine or fluid resuscitation. The main outcome is the occurrence of cardiovascular collapse within 30 minutes of drug administration. The study aims to inform safer drug choice during intubation and is expected to run until November 2025.

The Impact of Propofol and Ketamine on Cardiovascular Collapse During Induction for Intubation