Impact of Changing HIV Treatment on Drug Resistance in Adults with Suppressed HIV Infection

What this Trial Is About

Researchers are investigating the prevalence and impact of drug resistance mutations DRM in adults living with HIV who have their virus well controlled by antiretroviral therapy ART. The study focuses on understanding how changing HIV treatment regimens affects the presence of these mutations, especially in patients with full viral suppression and those with low level viremia LLV. It is a prospective observational study conducted in HIV specialist clinics. Participants include adults with HIV on ART who are either planning to switch their treatment regimen or are not planning a switch but may have LLV or undetectable viral levels. Blood samples are collected before switching, shortly after, and then again 2 to 3 years later. Sequencing of HIV-1 proviral DNA is performed to identify drug resistance mutations. Clinical data is also gathered for analysis. During the study, participants provide blood samples at specified times to measure changes in drug resistance mutations over short and long terms following regimen switch. Researchers assess the frequency of these mutations, the occurrence and timing of virological failure, and differences between patients with and without LLV. The study helps determine factors related to persistent resistance and informs clinical management. Participation spans from enrollment through follow-up visits over several years.

Impacts of HIV Treatment Regimens on Archived Drug Resistance