Actively Recruiting
IMPRoving Outcomes in Vascular DisEase - Aortic Dissection
Led by Duke University · Updated on 2026-04-29
1100
Participants Needed
63
Research Sites
324 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
T
The University of Texas Health Science Center, Houston
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether an upfront invasive strategy of TEVAR plus medical therapy reduces the occurrence of a composite endpoint of all-cause death or major aortic complications compared to an upfront conservative strategy of medical therapy with surveillance for deterioration in patients with uncomplicated type B aortic dissection.
CONDITIONS
Official Title
IMPRoving Outcomes in Vascular DisEase - Aortic Dissection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 21 years
- Diagnosis of Stanford type B aortic dissection not involving the aorta at or proximal to the innominate artery, without rupture or malperfusion syndrome, within 48 hours to 6 weeks after initial hospital admission
- Ability to provide written informed consent
- Investigator assessment that anatomy is suitable for thoracic endovascular aortic repair (TEVAR)
You will not qualify if you...
- Ongoing systemic infection
- Pregnant or planning pregnancy within the next 3 months
- Life expectancy less than 2 years due to non-aortic conditions
- Unwilling or unable to comply with all study procedures
- Known history of genetic aortopathy
- Penetrating aortic ulcer without concomitant uncomplicated type B aortic dissection
- Intramural hematoma without concomitant uncomplicated type B aortic dissection
- Iatrogenic (traumatic) aortic dissection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 63 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Honorhealth
Phoenix, Arizona, United States, 85020
Actively Recruiting
3
Memorial Care Long Beach Medical Center
Long Beach, California, United States, 90806
Actively Recruiting
4
Keck Medical Center of USC
Los Angeles, California, United States, 90033
Actively Recruiting
5
University of California San Diego
San Diego, California, United States, 92110
Withdrawn
6
University of California
San Francisco, California, United States, 94143
Actively Recruiting
7
Stanford University Medical Center
Stanford, California, United States, 94305
Withdrawn
8
University of Colorado Denver
Aurora, Colorado, United States, 80045
Actively Recruiting
9
Memorial Hospital Central
Colorado Springs, Colorado, United States, 90803
Actively Recruiting
10
Hartford Hospital
Hartford, Connecticut, United States, 06102
Actively Recruiting
11
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
12
University of Florida Health
Gainesville, Florida, United States, 32608
Actively Recruiting
13
Tampa General Hospital
Tampa, Florida, United States, 33606
Actively Recruiting
14
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
15
The University of Chicago
Chicago, Illinois, United States, 60637
Withdrawn
16
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
Actively Recruiting
17
Indiana University Methodist Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
18
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
19
MaineHealth
Scarborough, Maine, United States, 04101
Actively Recruiting
20
Johns Hopkins University
Baltimore, Maryland, United States, 21230
Actively Recruiting
21
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
22
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
23
University of Massachusetts Memorial
Worcester, Massachusetts, United States, 01655
Actively Recruiting
24
University of Michigan Health
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
25
Henry Ford Health System
Detroit, Michigan, United States, 48202
Actively Recruiting
26
Spectrum Health and Hospitals and Corewell
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
27
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
28
Mayo Clinic
Rochester, Minnesota, United States, 55905
Withdrawn
29
University of Missouri Health Care
Columbia, Missouri, United States, 65212
Actively Recruiting
30
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Withdrawn
31
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Withdrawn
32
Cooper University Hospital
Camden, New Jersey, United States, 08103
Actively Recruiting
33
Rutgers UH Vascular Center
Jersey City, New Jersey, United States, 07302
Actively Recruiting
34
Maimonides Medical Center
Brooklyn, New York, United States, 11219
Withdrawn
35
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
36
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
37
University of Rochester Medical Center
Rochester, New York, United States, 14642
Actively Recruiting
38
St. Francis Hospital and Heart Center
Roslyn, New York, United States, 11576
Actively Recruiting
39
Stony Brook University Medical Center
Stony Brook, New York, United States, 11794
Actively Recruiting
40
SUNY Upstate Medical University
Syracuse, New York, United States, 13120
Actively Recruiting
41
University of North Carolina Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Withdrawn
42
Sanger Heart & Vascular Institute
Charlotte, North Carolina, United States, 28201
Withdrawn
43
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
44
Harrington Heart and Vascular Institute
Cleveland, Ohio, United States, 44106
Actively Recruiting
45
The Ohio State University Medical Center
Columbus, Ohio, United States, 43210
Actively Recruiting
46
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
47
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
48
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
49
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
50
UT Dell Medical School- Ascension
Austin, Texas, United States, 78712
Actively Recruiting
51
Baylor Scott & White Research Institute
Dallas, Texas, United States, 75226
Actively Recruiting
52
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
53
Houston Methodist Hospital
Houston, Texas, United States, 77030
Actively Recruiting
54
The University of Texas Health Houston
Houston, Texas, United States, 77030
Actively Recruiting
55
Baylor Scott & White The Heart Hospital - Plano
Plano, Texas, United States, 75093
Actively Recruiting
56
University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
57
Sentara Cardiovascular Research Institute
Norfolk, Virginia, United States, 23507
Actively Recruiting
58
University of Washington
Seattle, Washington, United States, 98104
Actively Recruiting
59
CAMC Clinical Trials Center
Charleston, West Virginia, United States, 25304
Actively Recruiting
60
University of Wisconsin
Madison, Wisconsin, United States, 53792
Actively Recruiting
61
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
62
CHUM - Centre hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada, H2X 0C1
Actively Recruiting
63
McGill University Medical Center
Montreal, Quebec, Canada, H3A 0G4
Actively Recruiting
Research Team
M
Megan Roebuck, M.S.
CONTACT
K
Kady-Ann Steen-Burrell, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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