Actively Recruiting
Integrated Testing Strategy for Simultaneous Detection of ESR-1 and gBRCA Mutations Via Liquid Biopsy in HR+/HER2- Metastatic Breast Cancer (mBC) Patients,
Led by European Institute of Oncology · Updated on 2026-03-24
80
Participants Needed
1
Research Sites
314 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Development and validation of an integrated testing strategy for simultaneous detection of ESR-1 and gBRCA mutations via liquid biopsy in HR+/HER2- metastatic breast cancer (mBC) patients, and the creation of a digital gene library to support an evidence-based diagnostic algorithm
CONDITIONS
Official Title
Integrated Testing Strategy for Simultaneous Detection of ESR-1 and gBRCA Mutations Via Liquid Biopsy in HR+/HER2- Metastatic Breast Cancer (mBC) Patients,
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of estrogen receptor-positive (ER+) and/or progesterone receptor-positive (PgR+) breast cancer by histological or cytological examination
- Confirmed HER2-negative breast cancer by local laboratory testing (If IHC is 2+, a negative in situ hybridization test is required)
- Advanced or metastatic breast cancer, including patients before treatment initiation or after progression following CDK4/6 inhibitor treatment
- Primary tumor treated according to the standard of care
- Signed and dated written informed consent prior to inclusion
You will not qualify if you...
- Unable to provide written informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
European Institute of oncology
Milan, Italy, Italy, 20141
Actively Recruiting
Research Team
N
Nicola Fusco, MD
CONTACT
F
francesca lombardi, biologist
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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