Actively Recruiting

Age: 22Years +
All Genders
NCT06378632

AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

Led by Cordio Medical · Updated on 2025-03-26

500

Participants Needed

45

Research Sites

178 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Study Design: This is an international, multicenter, observational, non-interventional, prospective, blinded, single-arm, two-period study, to collect patient utterances that will be retrospectively analyzed to determine the sensitivity and UPNR of the HearO system.

CONDITIONS

Official Title

AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

Who Can Participate

Age: 22Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 22 years or older
  • Diagnosed with symptomatic chronic heart failure classified as NYHA II-IVa (ambulatory)
  • At least one of the following: one hospitalization for acute decompensated heart failure in the last 12 months, one unplanned intravenous/subcutaneous diuretic administration in the last 6 months, two unplanned intravenous/subcutaneous diuretic administrations in the last 12 months, or NTProBNP level greater than 500 pg/ml
  • Clinically stable heart failure as assessed by the investigator
  • Willing to participate and provide written informed consent
Not Eligible

You will not qualify if you...

  • Unable to comply with daily use of the HearO app
  • Major cardiovascular event within 3 months prior to enrollment
  • Cardiac resynchronization therapy device implanted or upgraded within 1 month prior to screening
  • Estimated glomerular filtration rate below 30 ml/min/1.73 m2
  • Likely to undergo heart transplantation or left ventricular assist device implantation within 6 months of screening
  • Treatment for significant chronic obstructive pulmonary disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 45 locations

1

Eastern Shore Research Institute

Fairhope, Alabama, United States, 36532

Actively Recruiting

2

UC San Diego Health

La Jolla, California, United States, 92037

Actively Recruiting

3

VA Loma Linda Healthcare System

Loma Linda, California, United States, 92357

Actively Recruiting

4

VA San Diego

San Diego, California, United States, 92161

Actively Recruiting

5

University of California, San Francisco

San Francisco, California, United States, 94117

Actively Recruiting

6

Kaiser Permanente San Francisco

San Francisco, California, United States, 94118

Actively Recruiting

7

Nature Coast Clinical Research

Crystal River, Florida, United States, 34429

Actively Recruiting

8

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States, 32216

Actively Recruiting

9

Amavita Clinical Research

Miami, Florida, United States, 33137

Actively Recruiting

10

Advance Medical Research Services Corp (AMRS)

Miami, Florida, United States, 33173

Actively Recruiting

11

Baptist Health (Miami Cardiac & Vascular Institute)

Miami, Florida, United States, 33173

Actively Recruiting

12

Comprehensive Medical & Research Center

Plantation, Florida, United States, 33317

Actively Recruiting

13

St. Johns Center for Clinical Research

Saint Augustine, Florida, United States, 32086

Actively Recruiting

14

Tampa General Hospital

Tampa, Florida, United States, 33606

Actively Recruiting

15

West Georgia Cardiology

Carrollton, Georgia, United States, 30117

Actively Recruiting

16

University of Chicago

Chicago, Illinois, United States, 60637

Actively Recruiting

17

Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States, 60657

Actively Recruiting

18

Advocate Illinois Masonic Health Center

Downers Grove, Illinois, United States, 60515

Actively Recruiting

19

Midwest Cardiovascular Center

Naperville, Illinois, United States, 60540

Actively Recruiting

20

Robert J. Dole VA Medical Center

Wichita, Kansas, United States, 67218

Actively Recruiting

21

St. Elizabeth Healthcare

Edgewood, Kentucky, United States, 41017

Actively Recruiting

22

Cardiovascular Institute of the South

Houma, Louisiana, United States, 70360

Actively Recruiting

23

Cardiovascular Institute of the South

Lafayette, Louisiana, United States, 70503

Actively Recruiting

24

University Medical Center New Orleans

New Orleans, Louisiana, United States, 70112

Actively Recruiting

25

Nebraska Heart Center

Lincoln, Nebraska, United States, 68526

Actively Recruiting

26

VA Southern Nevada Healthcare System

North Las Vegas, Nevada, United States, 89086

Actively Recruiting

27

Mount Sinai Morningside

New York, New York, United States, 10025

Actively Recruiting

28

The Mount Sinai Hospital

New York, New York, United States, 10029

Actively Recruiting

29

St. Francis Hospital

Roslyn, New York, United States, 11576

Actively Recruiting

30

Mission Hospital

Asheville, North Carolina, United States, 28803

Actively Recruiting

31

Moses H. Cone Memorial Hospital

Greensboro, North Carolina, United States, 27401

Actively Recruiting

32

The Lindner Research Center at The Christ Hospital

Cincinnati, Ohio, United States, 45219

Actively Recruiting

33

Cleveland Clinic

Cleveland, Ohio, United States, 44106

Actively Recruiting

34

The Ohio State University

Columbus, Ohio, United States, 43210

Actively Recruiting

35

Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37232

Actively Recruiting

36

Rio Grande Regional Hospital

McAllen, Texas, United States, 78503

Actively Recruiting

37

Methodist Hospital of San Antonio

San Antonio, Texas, United States, 78229

Actively Recruiting

38

University Hospital Samson Assuta Ashdod

Ashdod, Israel

Actively Recruiting

39

Assuta Be'er Sheva Medical Center

Beersheba, Israel

Actively Recruiting

40

Rambam Medical Center

Haifa, Israel

Actively Recruiting

41

Shaare Zedek Medical Center

Jerusalem, Israel

Actively Recruiting

42

Galiee Medical Center

Nahariya, Israel

Actively Recruiting

43

Tel Aviv Sourasky (Ichilov) Medical Center

Tel Aviv, Israel

Actively Recruiting

44

Poriya Medical Center

Tiberias, Israel

Actively Recruiting

45

Hospital Universitari Germans Trias i Pujol

Badalona, Spain, 08916

Actively Recruiting

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Research Team

B

Bill Tobin

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM | DecenTrialz