Actively Recruiting
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
Led by Prostate Cancer Clinical Trials Consortium · Updated on 2026-05-08
5000
Participants Needed
121
Research Sites
753 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry and recruit patients across academic and community practices from Australia, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, Spain, South Africa, Sweden, Switzerland, the United Kingdom (UK), and the United States (US). Target accrual number and number of participating sites are subject to change based on accrual, funding, and interest in participation by other international sites. This cohort study will facilitate a better understanding of the variation in care and treatment of advanced prostate cancer across countries and across academia and community based practices. Detailed data will be collected from patients at study enrollment and then during follow-up, for a minimum of five years. Patients will be followed prospectively for overall survival, clinically significant adverse events, comorbidities, changes in cancer treatments, and PROMs. PROMs questionnaires will be collected at enrollment and every three months thereafter. Physician Questionnaires will be collected from all participating sites at patient enrollment, time of first change in treatment and/or one year follow-up, at each subsequent change of treatment, and discontinuation of treatment. As such, this registry will help identify the treatment sequences or combinations that optimize overall survival and PROMs for men with mHSPC and M0/M1 CRPC. By collecting blood at enrollment, time of first change in treatment and/or one year follow-up (plasma, cell free DNA, buffy coat / RNA), this registry will further identify and validate molecular phenotypes of disease that predict response and resistance to specific therapeutics. Additionally, every effort will be made to collect blood specimen at each subsequent change in treatment due to progression of disease. When feasible, existing tumor tissue may be collected for correlation with described blood based studies. All samples will be used for future research. This cohort study will provide the research community with a unique biorepository to identify biomarkers of treatment response and resistance.
CONDITIONS
Official Title
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to provide written informed consent and privacy authorization for the release of personal health information
- Male, 21 years of age or older
- Histological or cytological confirmation of prostate adenocarcinoma from TRUS biopsy, radical prostatectomy, or TURP
- Or documented histopathology or cytopathology of prostate adenocarcinoma from a metastatic site biopsy
- Or metastatic prostate cancer involving bone or pelvic or para-aortic lymph nodes with serum PSA >20 ng/mL at initial diagnosis
You will not qualify if you...
- Previous diagnosis of a second, non-prostate malignancy requiring additional systemic therapy, except bladder cancer in situ or basal cell carcinoma of the skin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 121 locations
1
University of Alabama-Birmingham
Birmingham, Alabama, United States, 35233
Completed
2
University of Alabama- Tuscaloosa
Tuscaloosa, Alabama, United States, 35487
Actively Recruiting
3
University of California - Los Angeles
Los Angeles, California, United States, 90024
Terminated
4
University of California San Diego
San Diego, California, United States, 92037
Actively Recruiting
5
Yale University
New Haven, Connecticut, United States, 06502
Actively Recruiting
6
University of Florida
Gainesville, Florida, United States, 32611
Terminated
7
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32224
Actively Recruiting
8
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
9
Morehouse School of Medicine
Atlanta, Georgia, United States, 30310
Actively Recruiting
10
Emory Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
11
University of Illinois at Chicago
Chicago, Illinois, United States, 60607
Actively Recruiting
12
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
13
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
14
Kishwaukee Cancer Center
DeKalb, Illinois, United States, 60115
Actively Recruiting
15
Delnor Cancer Center
Geneva, Illinois, United States, 60134
Actively Recruiting
16
Warrenville Cancer Center
Warrenville, Illinois, United States, 60555
Actively Recruiting
17
Tulane University
New Orleans, Louisiana, United States, 70118
Active, Not Recruiting
18
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, United States, 21231
Actively Recruiting
19
Chesapeake Urology Associates
Towson, Maryland, United States, 21204
Terminated
20
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
21
University of Massachusetts Memorial Medical Center
Worcester, Massachusetts, United States, 01655
Actively Recruiting
22
University of Michigan
Ann Arbor, Michigan, United States, 48109
Terminated
23
Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Actively Recruiting
24
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
25
NewYork-Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, United States, 11215
Actively Recruiting
26
Roswell Park Comprehensive Cancer Center
Buffalo, New York, United States, 14203
Active, Not Recruiting
27
VA Western New York Healthcare System
Buffalo, New York, United States, 14215
Terminated
28
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
29
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
30
Weill Cornell Medical Center
New York, New York, United States, 10065
Actively Recruiting
31
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
32
Durham VA Medical Center
Durham, North Carolina, United States, 27705
Actively Recruiting
33
Duke Cancer Network
Durham, North Carolina, United States, 27710
Actively Recruiting
34
Duke University
Durham, North Carolina, United States, 27710
Actively Recruiting
35
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
36
Oregon Health & Science University Hospital
Portland, Oregon, United States, 97239
Actively Recruiting
37
Doylestown Health
Doylestown, Pennsylvania, United States, 18901
Completed
38
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Active, Not Recruiting
39
Fox Chase Cancer Center - Temple Health
Philadelphia, Pennsylvania, United States, 19134
Actively Recruiting
40
Reading Health System
West Reading, Pennsylvania, United States, 19611
Actively Recruiting
41
Ralph H. Johnson VA Medical Center
Charleston, South Carolina, United States, 29401
Actively Recruiting
42
William Jennings Bryan Dorn VAMC
Columbia, South Carolina, United States, 29209
Terminated
43
Memphis VA Medical Center
Memphis, Tennessee, United States, 38104
Actively Recruiting
44
Baptist Clinical Research Institute
Memphis, Tennessee, United States, 38120
Actively Recruiting
45
Baylor College of Medicine
Houston, Texas, United States, 77030
Completed
46
University of Virginia
Charlottesville, Virginia, United States, 22903
Actively Recruiting
47
University of Washington Medical Center
Seattle, Washington, United States, 98195
Active, Not Recruiting
48
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, United States, 53705
Actively Recruiting
49
Royal Brisbane & Women's Hospital
Herston, Brisbane, Australia
Actively Recruiting
50
St. Vincent's Hospital Sydney
Darlinghurst, New South Wales, Australia
Actively Recruiting
51
Macquarie University
Sydney, New South Wales, Australia
Actively Recruiting
52
Westmead Hospital
Sydney, New South Wales, Australia
Actively Recruiting
53
Redland Hospital
Cleveland, Queensland, Australia
Actively Recruiting
54
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Actively Recruiting
55
Eastern Health (Box Hill Hospital)
Box Hill, Victoria, Australia
Actively Recruiting
56
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia, 3000
Actively Recruiting
57
Epworth Healthcare
Mount Waverley, Victoria, Australia, 3149
Actively Recruiting
58
Australian Urology Associates
Melbourne, Australia
Actively Recruiting
59
Australian Prostate Centre
Melbourne N., Australia
Actively Recruiting
60
The University of the West Indies - Cave Hill Campus
Bridgetown, Barbados
Actively Recruiting
61
Tacchini Hospital
Bento Gonçalves, Rio Grande do Sul, Brazil, 95700-084
Active, Not Recruiting
62
Hospital Beneficência Portuguesa
Bela Vista, São Paulo, Brazil
Terminated
63
Instituto do Câncer e Transplante
Curitiba, Brazil
Completed
64
Centro de Pesquisa em Oncologia
Porto Alegre, Brazil
Active, Not Recruiting
65
Centro Paulista de Oncologia
São Paulo, Brazil
Active, Not Recruiting
66
Instituto Câncer do Estado de São Paulo
São Paulo, Brazil
Completed
67
Cross Cancer Institute (Alberta Health Services)
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
68
BC Cancer Agency
Vancouver, British Columbia, Canada
Actively Recruiting
69
Juravinski Cancer Centre
Hamilton, Ontario, Canada
Actively Recruiting
70
Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada
Actively Recruiting
71
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2C1
Actively Recruiting
72
Centre hospitalier de l'Université de Montréal (CHUM)
Montreal, Quebec, Canada
Actively Recruiting
73
CHU de Québec-Université Laval
Québec, Quebec, Canada
Actively Recruiting
74
Beacon Hospital
Dublin, Leinster, Ireland
Actively Recruiting
75
Tallaght University Hospital
Dublin, Ireland, D24 NR0A
Actively Recruiting
76
St. Vincent's University Hospital
Dublin, Ireland
Actively Recruiting
77
Sligo University Hospital
Sligo, Ireland, F91 H684
Actively Recruiting
78
The University of the West Indies - Mona Campus
Kingston, Jamaica
Actively Recruiting
79
University of Nairobi
Nairobi, Kenya
Actively Recruiting
80
Federal Medical Centre Abeokuta
Abeokuta, Nigeria
Active, Not Recruiting
81
University of Ilorin Teaching Hospital
Ilorin, Nigeria
Active, Not Recruiting
82
Lagos State University Teaching Hospital
Lagos, Nigeria
Active, Not Recruiting
83
University of Maiduguri Teaching Hospital
Maiduguri, Nigeria
Active, Not Recruiting
84
Oslo University Hospital
Oslo, Norway, 0379
Actively Recruiting
85
The Medical Oncology Centre of Rosebank
Johannesburg, Gauteng, South Africa, 2196
Active, Not Recruiting
86
Steve Biko Academic Hospital
Pretoria, Gauteng, South Africa, 0084
Active, Not Recruiting
87
Groote Schuur Hospital
Cape Town, South Africa, 7925
Active, Not Recruiting
88
Hospital Clínic de Barcelona
Barcelona, Barcelona, Spain
Active, Not Recruiting
89
Vall d'Hebron Institute of Oncology
Barcelona, Catalonia, Spain
Active, Not Recruiting
90
Hospital Universitario Virgen de la Victoria
Málaga, Málaga, Spain
Active, Not Recruiting
91
Instituto Valenciano de Oncología
Valencia, Valencia, Spain, 46009
Active, Not Recruiting
92
Institut Catalá d'Oncologia Badalona
Badalona, Spain
Active, Not Recruiting
93
Fundació Institut Mar d'Investigacions Mèdiques (Hospital del Mar).
Barcelona, Spain
Active, Not Recruiting
94
Hospital Provincial de Castellón
Castellon, Spain
Active, Not Recruiting
95
Hospital Universitario La Princesa
Madrid, Spain, 28006
Active, Not Recruiting
96
Hospital Clinico San Carlos
Madrid, Spain
Active, Not Recruiting
97
Hospital Universitario 12 de Octubre
Madrid, Spain
Active, Not Recruiting
98
Hospital Universitario Central de Asturias
Oviedo, Spain, 33011
Active, Not Recruiting
99
Hospital Universitario Miguel Servet (Zaragoza)
Zaragoza, Spain
Active, Not Recruiting
100
Skane University Hospital
Malmö, Skåne County, Sweden
Actively Recruiting
101
Umea University Hospital
Umeå, Sweden, Sweden, 907 37
Actively Recruiting
102
Orebro University Hospital
Örebro, Sweden
Actively Recruiting
103
Ente Ospedaliero Cantonale
Bellinzona, Bellinzona, Switzerland, 6500
Active, Not Recruiting
104
Universitätsspital Basel
Basel, Switzerland
Active, Not Recruiting
105
Kantonsspital Graubünden
Chur, Switzerland
Active, Not Recruiting
106
Kantonsspital St. Gallen
Sankt Gallen, Switzerland
Active, Not Recruiting
107
Onkozentrum Zürich
Zurich, Switzerland, 8039
Active, Not Recruiting
108
Universitätsspital Zürich
Zurich, Switzerland
Active, Not Recruiting
109
University Hospital Southampton NHS Foundation Trust
Southampton, Hampshire, United Kingdom
Actively Recruiting
110
Lister Hospital
Stevenage, Hertfordshire, United Kingdom, SG1 4AB
Actively Recruiting
111
Mount Vernon Cancer Centre
Northwood, Middlesex, United Kingdom, HA6 2RN
Actively Recruiting
112
Velindre Cancer Centre
Cardiff, United Kingdom
Actively Recruiting
113
University Hospitals of Morecambe Bay NHS Foundation Trust
Lancaster, United Kingdom
Actively Recruiting
114
Guys St Thomas NHS Foundation Trust
London, United Kingdom
Actively Recruiting
115
The Royal Marsden NHS Foundation Trust
London, United Kingdom
Actively Recruiting
116
The Christie NHS Foundation Trust
Manchester, United Kingdom
Actively Recruiting
117
Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, United Kingdom
Actively Recruiting
118
Lancashire Teaching Hospitals NHS Foundation Trust
Preston, United Kingdom, PR2 9HT
Actively Recruiting
119
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom, S10 2SB
Actively Recruiting
120
South Tyneside District Hospital
South Shields, United Kingdom, NE34 0PL
Terminated
121
Sunderland Royal Hospital
Sunderland, United Kingdom, SR4 7TP
Terminated
Research Team
J
Jacob Vinson
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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